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Updated: Jan 8, 2026

Quantification of the Immunosuppressant Tacrolimus on Dried Blood Spots Using LC-MS/MS
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Quantification of the Immunosuppressant Tacrolimus on Dried Blood Spots Using LC-MS/MS

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在CYP3A5*6与*3功能丧失等位基因携带者中较低剂量-正常化的塔克罗利斯暴露:在脏移植接受者中进行的一项长度回顾性现实世界研究

Amar D Levens1, Dirk Jan A R Moes1, Yanick Boer1

  • 1Department of Clinical Pharmacy and Toxicology, Leiden University Medical Center, Leiden, The Netherlands.

Clinical pharmacology and therapeutics
|December 23, 2025
PubMed
概括

基因变异CYP3A5*6显著降低了移植患者,特别是非洲血统患者的塔克罗利暴露. 这一发现解决了药物基因组学中的不足,并促进了健康公平.

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