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含的酸通过微RNA介导的信号传递减轻了Pb诱导的记忆障碍

Fengjiao Fan¹, Nanlong Li¹, Wenqian Tang¹

¹College of Food Science and Engineering, Nanjing University of Finance and Economics/Collaborative Innovation Center for Modern Grain Circulation and Safety, Nanjing 210023, China. fangyong10@nufe.edu.cn.

Food & function

|December 23, 2025

概括

类酸TSeMMM和SeMDPGQQ通过减少海马体的氧化应激来保护免受诱导的记忆丧失. 这些也调节了特定的microRNA,提供了新的治疗见解.

科学领域:

神经科学是一个神经科学.
毒理学毒理学毒理学
分子生物学分子生物学

背景情况:

(Pb) 在海马体积聚会会导致氧化应激和记忆障碍.
含的酸显示出减轻Pb诱导的神经毒性的潜力.
了解微RNA在介导记忆保护中的作用至关重要.

研究的目的:

为了研究酸TSeMMM和SeMDPGQQ对酸诱导的记忆缺陷的神经保护作用.
探索microRNAs在这些的记忆保护机制中的参与.
阐明对海马体氧化应激和神经元形态学的影响.

主要方法:

通过酸管理诱导的记忆障碍的小鼠模型.
评估Pb积累,氧化应激标志物和海马神经元形态.
对来自大脑的神经营养因子 (BDNF) 表达和Keap1/Nrf2通路的分析.
微RNA测序以识别差异表达的微RNA.

主要成果:

TSeMMM和SeMDPGQQ治疗逆转了海马中的积累和氧化应激.
观察到改善的海马神经元形态和调节的BDNF表达和Keap1/Nrf2通路.
的使用改变了26个微RNA;高剂量的TSeMMM和低剂量的SeMDPGQQ恢复了其中的4个.

结论:

酸TSeMMM和SeMDPGQQ有效地缓解诱导的神经毒性和记忆障碍.
这些调节海马体的氧化应激,神经元形态和特定的微RNA表达.
这些发现突出了丰富的因素作为神经毒性治疗的有前途的治疗剂.

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MicroRNAs

MicroRNAs

MicroRNA (miRNA) are short, regulatory RNA transcribed from introns (non-coding regions of a gene) or intergenic regions (stretches of DNA present between genes). Several processing steps are required to form biologically active, mature miRNA. The initial transcript, called primary miRNA (pri-mRNA), base-pairs with itself, forming a stem-loop structure. Within the nucleus, an endonuclease enzyme, called Drosha, shortens the stem-loop structure into hairpin-shaped pre-miRNA. After the pre-miRNA...

MicroRNAs

MicroRNAs

MicroRNA (miRNA) are short, regulatory RNA transcribed from introns—non-coding regions of a gene—or intergenic regions—stretches of DNA present between genes. Several processing steps are required to form biologically active, mature miRNA. The initial transcript, called primary miRNA (pri-mRNA), base-pairs with itself forming a stem-loop structure. Within the nucleus, an endonuclease enzyme, called Drosha, shortens the stem-loop structure into hairpin-shaped pre-miRNA. After...