静脉内注射和青光眼之间的关联:一个更新
Chi Phan1, Mary Qiu2, Alice Yang Zhang1
1Department of Ophthalmology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina.
Current opinion in ophthalmology
|December 23, 2025
概括
静脉内抗血管内皮生长因子 (VEGF) 注射可以导致暂时或持续的眼内高压 (IOP),危及视神经损伤. 个性化管理和预防措施是缓解视网膜疾病患者这些并发症的关键.
科学领域:
- 眼科医生 眼科 眼科
- 视网膜疾病 视网膜疾病
- 血管生物学 血管生物学
背景情况:
- 静脉内抗VEGF注射是视网膜疾病的标准.
- 有关眼内压力 (IOP) 相关并发症存在担忧.
- 了解IOP动态对于患者安全至关重要.
研究的目的:
- 审查目前关于抗VEGF注射后IOP变化的证据.
- 为了检查短暂和持续的内压升高.
- 讨论结构/血管效应和管理策略.
主要方法:
- 对最近关于抗VEGF注射和IOP的研究的文献综述.
- 对影响IOP峰值和持续升高的因素的分析.
- 评估临床结果和管理方法.
主要成果:
- 急性IOP峰值很常见,通常在一个小时内消失,但在青光眼/OHT中会延迟.
- 尖峰的大小因患者和技术因素而异.
- 持续升高与特定药物和累积注射有关,可能导致RNFL稀薄,需要进行眼手术.
结论:
- 标准协议是不够的,需要个性化管理.
- 预防策略,仔细选择药剂和多学科护理可以减少IOP相关的风险.
- 缓解并发症需要针对敏感患者量身定制的方法.
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