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在引肌中注射肉毒素对患有性脑的低功能儿童的毛细运动功能的影响

Jun Min Cha¹, Jehyun Yoo¹, Juntaek Hong¹

¹Department and Research Institute of Rehabilitation Medicine, Yonsei University College of Medicine, Seoul, Korea.

Yonsei medical journal

|December 23, 2025

概括

毒素A型 (BoNT-A) 注射改善了低功能的脑 (CP) 的儿童在GMFCSIII-V级别的总运动功能. 无论注射地点如何,在整体功能和特定领域都出现了改善.

科学领域:

儿科神经学儿科神经学
康复医学康复医学康复医学
运动障碍运动障碍

背景情况:

大脑 (CP) 显著影响儿童的毛细运动功能.
低功能的CP (GMFCS水平III-V) 在控制性方面存在独特的挑战,特别是在部附加肌肉中.
毒素A型 (BoNT-A) 是一种常见的治疗方法,但它对严重CP的总运动功能的影响需要进一步调查.

研究的目的:

评估BoNT-A注射在改善低功能的CP儿童 (GMFCSIII-V级) 的毛细运动功能的有效性.
评估BoNT-A对特定功能领域和不同注射部位组合的影响.

主要方法:

对100名患有CP的学前儿童 (GMFCS III-V) 进行了回顾性研究,这些儿童接受了添加剂BoNT-A注射.
总运动功能的测量 (GMFM) 在注射前和后 (3周至4个月) 评估.
使用威尔科克森签名等级试验进行统计比较,根据GMFCS水平和注射部位对子组进行分析.

主要成果:

在所有GMFCS级别中观察到显著的GMFM得分改善 (p<0.05).
在GMFCS III和IV的儿童显示在所有领域 (A-E) 的收益;GMFCS V显示在领域A,B和C的收益 (p<0.05).
只有添加器,添加器-腿筋和添加器-远距离肌肉注射的显著改善 (p<0.05).

结论:

针对部附加肌肉的BoNT-A注射有效地改善了CP功能低下的儿童的毛细运动功能.
功能性改善涵盖整体和特定领域,无论注射单独针对辅助器还是与其他肌肉群结合.

关键词:

脑性麻脑性麻是一种疾病.肉毒毒素是一种毒素.机动功能机动功能机动功能性,性,性,性,性,性,性,性,性,性,性,性,性,性,性,性,性,性,性,性,性,性,性,性,性,性,性,性,性,性,性,性,性,性,性,性,性,性,性,性,性,性,性,性,性,性,性,性,性,性,性,性,性,性,性,性,性,性,性,性,性,性等.

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