尿氨酶在急性胰腺炎的诊断效用:一个系统性审查
Ubaid Ullah1, Syed Saad Ali Chishti2, Asim Junaid3
1Vascular Surgery, Beaumont Hospital, Dublin, IRL.
Cureus
|December 23, 2025
概括
尿氨酶和辛素-2在诊断急性胰腺炎 (AP) 中具有很高的准确性,匹配或超过血清测试. 这些非侵入性尿路生物标志物为AP诊断提供了可靠的替代方案.
科学领域:
- 胃肠病学和肝病学 胃肠学和肝病学
- 临床诊断 临床诊断 临床诊断
- 生物标志物研究 生物标志物研究
背景情况:
- 急性胰腺炎 (AP) 诊断依赖于血清氨酶/脂酶,这可能是不可靠的.
- 尿氨酶提供了一个潜在的更敏感的选择,具有更长的检测窗口和更容易的样本采集.
- 对于AP的尿氨酶诊断准确性的现有证据是不一致的.
研究的目的:
- 系统地审查评估尿氨酶在急性胰腺炎的诊断准确性的研究.
- 为了比较尿氨酶与常规血清标记物的性能,用于AP诊断.
主要方法:
- 在主要数据库 (PubMed,Embase等) 中进行全面的文献搜索. 从2010年1月到2025年5月.
- 在疑似或已确认的AP中,包括尿氨酶的观察性,前性和诊断准确性研究.
- 使用QUADAS-2工具进行质量评估,并提取灵敏度,特异性,预测值和AUC.
主要成果:
- 十三项研究评估了AP中的尿氨酶和试素-2 .
- 灵敏度在62.9%至100%之间,特异性在42.9%至100%之间,AUC高达1.0.
- 尿路生物标志物表现与血清标志物相比或优于血清标志物,具有高负预测值 (高达98.3%).
结论:
- 尿氨酶和试素-2是AP诊断的敏感,可靠的生物标志物.
- 这些尿检等于或超过血清标记,支持它们作为一线或辅助诊断工具的使用.
- 建议进行标准化和多中心验证,以实现尿路生物标志物的最佳临床应用.
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