探索高血压和骨质疏松症之间的相互作用:叙述审查
Yolanda Gutierrez1, Ronald A Shaju1, Alyssa Sepulveda1
1School of Medicine, University of Texas Rio Grande Valley School of Medicine, Edinburg, USA.
Cureus
|December 23, 2025
概括
高血压和骨质疏松症有共同的途径,如氧化应激和RAAS激活,影响血管和骨健康. 对于这些普遍的慢性疾病,需要综合管理策略.
科学领域:
- 心血管医学 心血管医学
- 内分泌学 在内分泌学.
- 老年学是一门学科.
背景情况:
- 高血压和骨质疏松症是普遍存在的慢性疾病,具有显著的全球健康影响,特别是在老龄化人口中.
- 这些情况传统上被认为是独立的,但新兴的研究表明共享的病理生理联系.
- 了解这些联系对于改善查和综合管理至关重要.
研究的目的:
- 审查目前关于高血压和骨质疏松症之间的病理生理学联系的文献.
- 确定共同的机制,有助于血管和骨的恶化.
- 探索对综合管理策略和药理干预措施的影响.
主要方法:
- 在2024年1月至2025年7月期间发表的研究的叙述性综述.
- 在PubMed,ScienceDirect和Google Scholar中使用特定的布尔字符串和药理术语进行了搜索.
- 总共有336篇文章被检索,其中61篇在选相关性和质量后被选中.
主要成果:
- 氧化应激和氨酸- ангиотензин- 氨酸系统 (RAAS) 的激活是将高血压与骨质疏松症联系起来的关键机制.
- 这些途径有助于内皮功能障碍,骨质细胞活性增加和骨质细胞功能减少.
- 雌激素缺乏会加剧血管和骨的衰退. 一些抗高血压药物对骨有好处,而骨质疏松症药物对心血管有混合作用.
结论:
- 高血压和骨质疏松症通过共同的生物学途径相互联系,影响血管和骨健康.
- 认识到这些联系可以为双重治疗方法的发展提供信息.
- 需要进一步的研究,以建立有效的综合干预措施,同时管理这两种情况.
相关概念视频
Hypertension II: Pathophysiology
700
Hypertension is a chronic condition in which the blood's force against artery walls is excessively high, posing risks such as heart disease. The condition's underlying mechanisms involve complex interactions among the cardiovascular, kidney, and autonomic nervous systems.Renin-Angiotensin-Aldosterone System (RAAS): This system significantly influences blood pressure regulation. When blood pressure decreases, the kidneys secrete renin. This enzyme transforms angiotensinogen, a plasma protein,...
700
Bone Disorders
5.0K
Aging and its effect on bone remodeling is the most common cause of bone disorders. In young and healthy people, bone deposition and resorption happen at an equal rate to maintain optimal bone health.
Bone deposition is also affected by the levels of sex hormones like estrogen and testosterone that promote osteoblast activity and bone matrix synthesis. When the level of these hormones decreases due to aging, it causes a reduction in bone deposition. As a result, bone resorption by osteoclasts...
Bone deposition is also affected by the levels of sex hormones like estrogen and testosterone that promote osteoblast activity and bone matrix synthesis. When the level of these hormones decreases due to aging, it causes a reduction in bone deposition. As a result, bone resorption by osteoclasts...
5.0K
Hypertension and Regulation of Blood Pressure
3.6K
Hypertension, the most common cardiovascular disease, is diagnosed through repeated measurements of elevated blood pressure. Its risks, including damage to the kidney, heart, and brain, are directly proportional to blood pressure levels. Starting from 115/75 mm Hg, the risk of cardiovascular disease doubles with each increment of 20/10 mm Hg. The diagnosis relies on blood pressure measurements, not on patient symptoms, as hypertension is often asymptomatic until end-organ damage is imminent or...
3.6K
Hypertension III: Clinical Manifestations and Diagnostic Studies
437
Hypertension is asymptomatic and also referred to as the "silent killer" until it progresses to a severe stage or causes target organ disease. Patients may experience symptoms stemming from the strain on blood vessels and tissues in various organs or the heart's increased workload.Physical exams might show no abnormalities other than high blood pressure. Signs of vascular damage, when present, correspond to the organs supplied by the affected vessels, leading to target organ damage. For...
437
Hypertension V: Nursing Management
332
The nursing management of hypertension involves accurately assessing symptoms, making a comprehensive nursing diagnosis, collaborating with patients to set goals, and implementing targeted interventions to mitigate the condition's impact and improve patient well-being.Comprehensive AssessmentThe initial step in nursing care for hypertension involves a thorough patient assessment. It includes evaluating symptoms such as headaches, dizziness, blurred vision, and previous hypertension episodes.
332
Bone Remodeling
40.2K
Bone remodeling is a continuous and balanced process of bone resorption by osteoclasts and bone formation by osteoblasts. In adults, it helps maintain bone mass and calcium homeostasis. While mechanical stress can stimulate turnover as part of the normal maintenance and reparative process, several hormones also regulate bone remodeling.
40.2K
