一个小儿脊椎骨髓炎病例是由聚合菌aphrophilus引起的:第一个报告
Morihide Kanawa1, Naonori Maeda2, Munehiro Furuichi3
1Training and Education, National Hospital Organization (NHO) Tokyo Medical Center, Tokyo, JPN.
Cureus
|December 23, 2025
概括
由Aggregatibacter aphrophilus引起的儿科脊椎骨髓炎是罕见的. 这一案例突出显示了一名11岁男孩使用16S rRNA基因测序和抗生素的成功诊断和治疗.
科学领域:
- 传染性疾病 传染性疾病
- 儿科整形外科 儿科整形外科
- 微生物学 微生物学
背景情况:
- 发烧性脊椎骨质炎在儿童中不常见,这给诊断和治疗带来了挑战.
- 识别特定的致病原体对于有效的抗微生物选择至关重要.
研究的目的:
- 报告第一个由Aggregatibacter aphrophilus引起的脊椎骨质炎的儿童病例.
- 审查现有的关于儿童Aggregatibacter aphrophilus相关感染的文献.
主要方法:
- 16S rRNA基因测序的椎间盘活检和血液培养.
- 儿科患者的临床表现分析.
- 对25个之前报告的病例 (1983-2025) 的文献综述.
主要成果:
- 聚合菌 (Aggregatibacter aphrophilus) 被确定为11岁男孩长期发烧和背部疼痛的致病原体.
- 患者在六周的静脉注射和两周的口服抗生素治疗后完全康复.
- 没有需要手术干预.
结论:
- 在健康的儿童中,Aggregatibacter aphrophilus可以引起严重的侵入性感染,包括脊椎骨质炎.
- 16S rRNA基因测序是用于确诊罕见儿科感染的宝贵工具.
- 及时诊断和适当的抗生素治疗可以在没有手术的情况下带来良好的结果.
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