片成对肝功能和胆道结石患者胆道结石的影响:一项病例对照研究
Maedeh Abedinzadeh1, Mehdi Karimi2, Fatemeh Ahmadi Hajikolaei3
1Department of Internal Medicine, Babol University of Medical Sciences, Babol, Iran.
Addiction & health
|December 23, 2025
概括
患有胆道结石的患者的片成显著提高肝酶 (AST,ALT) 和胆红素,并扩大普通胆道 (CBD). 胰腺管径和ALP水平没有受到影响,这表明片.
科学领域:
- 肝病学和胃肠道学
- 临床毒理学 临床毒理学
- 成 药物 药物 药物 药物
背景情况:
- 胆道结石是一种影响肝胆道系统的常见疾病.
- 片成在某些地区普遍存在,并可能影响各种生理过程.
- 在患有胆道结石的患者中,片对肝功能和胆道的影响需要进一步研究.
研究的目的:
- 调查片成对肝功能测试 (LFTs) 和胆道尺寸的影响,诊断为胆道结石的患者.
- 为了比较阿片成者和非成者之间的这些影响,有胆道结石.
主要方法:
- 在伊朗进行了一项病例控制研究,涉及2016年至2017年期间86名胆道结石患者.
- 患者被分为两组:阿片成者 (n=40) 和非阿片成者 (n=46).
- 肝胆系统评估包括肝功能测试 (LFT) 和内镜超声波 (EUS);数据使用SPSS软件进行分析.
主要成果:
- 与对照组相比,成的患者表现出明显更高的阿斯巴酸胺转移酶 (AST) 和氨酸胺转移酶 (ALT) 水平.
- 在阿片成组中观察到直接和总胆红素水平的升高.
- 在阿片成的个体中发现,普通胆管 (CBD) 的直径显著更大,而胰腺管直径和性酸酶 (ALP) 水平没有显著差异.
结论:
- 在患有胆管结石的患者中,片成与肝酶,胆红素水平和常见胆管直径的显著变化有关.
- 这些发现表明,片使用对肝胆系统有显著影响.
- 需要进一步的研究来阐明片成对肝脏和胆道健康的长期影响,并指导临床管理策略.
相关概念视频
Effect of Hepatic Disease on Pharmacokinetics: Pathophysiologic Assessment and Liver Function Test
165
In clinical practice, the direct measurement of hepatic blood flow to evaluate liver function presents significant challenges due to the intricate and specialized nature of the necessary techniques. Consequently, healthcare professionals often rely on empirical estimates derived from thorough patient examinations and liver function tests to gauge liver health. Among the tools at their disposal, the Child–Pugh and MELD scoring systems stand out for their ability to categorize and assess...
165
Pharmacokinetics in Obese Patients: Drug Metabolism and Excretion
153
Drug metabolism, a critical process in the liver, involves two primary phases: Phase I reactions and Phase II conjugation. Obesity introduces significant alterations in this metabolic process, primarily due to fatty infiltration of the liver, leading to conditions such as nonalcoholic fatty liver disease (NAFLD). This condition can modify the activities of both Phase I and II enzymes, impacting how drugs are metabolized in obese patients.Phase I metabolism sees variable effects across...
153
Diseases of the Liver and Gallbladder
1.8K
Liver and gallbladder diseases are a significant health concern, with prominent conditions including cirrhosis, hepatitis, non-alcoholic fatty liver disease (NAFLD), and gallstones. Jaundice is a common manifestation of liver and biliary disease.
Cirrhosis is characterized by the scarring of hepatic lobules in the liver, which are replaced by fibrous tissue, affecting the liver's normal functioning. NAFLD, on the other hand, is caused by an excessive build-up of fat in the liver, not...
Cirrhosis is characterized by the scarring of hepatic lobules in the liver, which are replaced by fibrous tissue, affecting the liver's normal functioning. NAFLD, on the other hand, is caused by an excessive build-up of fat in the liver, not...
1.8K
Chronic Bowel Disorders: Introduction
722
Chronic bowel diseases are a group of long-term conditions affecting the digestive tract, characterized by inflammation and damage to the gut lining. These conditions primarily include irritable bowel syndrome and inflammatory bowel disease.
Irritable Bowel Syndrome (IBS) is a common disorder affecting the gastrointestinal tract. The distinctive feature is recurrent abdominal pain associated with altered bowel movements, manifesting as constipation, diarrhea, or fluctuating between both. The...
Irritable Bowel Syndrome (IBS) is a common disorder affecting the gastrointestinal tract. The distinctive feature is recurrent abdominal pain associated with altered bowel movements, manifesting as constipation, diarrhea, or fluctuating between both. The...
722
Hepatic Drug Excretion: Influencing Factors
502
The biliary system of the liver, crucial for bile secretion and drug excretion, comprises intrahepatic bile ducts that merge to form the common hepatic duct. This duct, carrying hepatic bile, combines with the cystic duct, draining the gallbladder and forming the common bile duct, which empties into the duodenum. Bile, produced by hepatic cells lining the bile canaliculi, is composed primarily of water, bile salts, pigments, electrolytes, and lesser amounts of cholesterol and fatty acids. Bile...
502
Effect of Hepatic Disease on Pharmacokinetics: Drug Dosing and Hepatic Blood Flow
197
Chronic liver disease significantly impacts drug metabolism due to alterations in hepatic blood flow and enzyme accessibility. This disruption affects the body's pharmacokinetics—the movement and processing of drugs within the system. Key enzymes crucial for metabolizing medications become less accessible, changing how drugs are processed and utilized. Furthermore, liver disease influences the synthesis of plasma proteins, such as albumin and globulins, which play critical roles in drug...
197


