患者报告的关节和膝关节骨关节炎综合管理计划的结果
Trevor A Lentz1,2,3, Preston Roundy4, Emily Poehlein5
1Duke Clinical Research Institute, Durham, NC, USA.
Osteoarthritis and cartilage open
|December 23, 2025
概括
参与美国骨关节炎管理计划的患者在两年内,部和膝盖功能显著改善. 大多数人都取得了临床上有意义的结果,这表明这些计划是手术的有效替代方案.
科学领域:
- 整形外科 整形外科 整形外科
- 类风湿病学 类风湿病学
- 康复医学 康复医学 康复医学
背景情况:
- 骨关节炎 (OA) 显著影响关节功能和生活质量.
- 综合性骨关节炎管理计划 (OAMPs) 旨在改善患者的治疗结果.
- 了解OA患者的长期功能变化对于治疗规划至关重要.
研究的目的:
- 为了评估美国OAMP的患者在2年内自我报告的关节功能结果.
- 确定与关节功能变化相关的人口因素.
- 评估患者中达到临床重要差异最小 (MCID) 的比例.
主要方法:
- 对598名关节骨质炎患者和1533名膝关节骨质炎患者的回顾性分析.
- 用HOOS JR和KOOS JR问卷在多个时间点评估的关节功能,最多2年.
- 用于结果分析的概括估计方程 (GEE) 和卡普兰梅尔曲线.
主要成果:
- 在两年内,在部和膝盖骨关节炎患者中观察到关节功能的统计显著改善.
- 在两年内,61%的膝关节OA和60%的关节OA患者达到MCID值.
- 就业状况,性别和基线功能影响了HOOS JR得分轨迹.
结论:
- 美国的OAMPs导致部和膝盖OA症状的平均改善.
- 大多数患者在2年内实现了临床上有意义的功能改善.
- 综合性OAMP显示出作为有效的非手术治疗选择的潜力.
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