在患有类风湿性关节炎的患者中模仿血管炎的原发性皮肤加密球菌病
Fatmanur Pepe1, Derya Seyman1, Sacide Nur Aksoy1
1Health Sciences University, Antalya Education and Research Hospital, Department of Infectious Diseases and Clinical Microbiology, Antalya, Türkiye.
The new microbiologica
|December 23, 2025
概括
本病例报告详细介绍了一例罕见的原发性皮肤加密球菌病例,该病例发生在患有类风湿性关节炎的免疫功能低下患者身上. 早期诊断和治疗对于管理非艾滋病毒患者这种机会性真菌感染至关重要.
科学领域:
- 菌类学 菌类学是指菌类学.
- 皮肤病学 皮肤病学
- 免疫功能受损的宿主感染
背景情况:
- 这是Cryptococcus spp. 是已知的机会性病原体,主要在感染艾滋病毒的个体中.
- 最近的趋势表明,在其他免疫功能低下的患者群体中,加密球菌病的发病率正在增加.
- 长期使用皮质类固醇治疗类风湿性关节炎 (RA) 可能使患者易患机会性感染.
研究的目的:
- 报告一种罕见的原发性皮肤加密球菌病例.
- 强调在没有艾滋病毒的免疫受损患者的诊断挑战和临床表现.
- 强调在不愈合的皮肤病变中考虑真菌感染的重要性.
主要方法:
- 一个73岁的男性患有类风湿性关节炎,长期服用皮质类固醇的临床病例介绍.
- 皮肤活检的组织病理学检查,使用周期性酸-Schiff (PAS) 和粘胺染色.
- 血清学加密球菌抗原测试.
主要成果:
- 这位患者出现了痛苦的,无法愈合的性瘤病变和出血球块.
- 皮肤活检揭示了与Cryptococcus一致的酵母形式,通过PAS和粘胺污染物证实了这一点.
- 阳性血清密码球菌抗原测试.
- 随着可纳治疗,临床症状的部分改善.
结论:
- 初级皮肤加密球菌病是一种罕见但严重的机会性感染,发生在免疫功能低下的患者身上,包括那些接受皮质类固醇治疗的RA患者.
- 皮肤真菌感染应在免疫受损个体的非愈合性皮肤病变的差异诊断中考虑.
- 尽管接受了治疗,但患者因其潜在的全身性疾病的并发症而死亡,这凸显了这种人群中机会性感染的严重性.
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