在急性情况下使用毒药物和开始置换疗法:单中心回顾性研究
Ohoud Aljuhani1, Raneem Bukhari2, Huda Aljedaani3
1Department of Pharmacy Practice, Faculty of Pharmacy, King Abdulaziz University, Jeddah, Saudi Arabia.
概括
某些药物如皮佩拉西林/塔扎巴克坦,万科米辛和ACE抑制剂增加了急性损伤 (AKI) 的风险,需要在住院患者中进行替代疗法 (RRT). 早期识别风险患者对于预防严重损伤至关重要.
科学领域:
- 腎臟病學 (nephrology) 是一種醫學.
- 药理学 药理学是指药理学的学科.
- 内部医学 内部医学
背景情况:
- 急性损伤 (AKI) 是住院患者常见和严重的并发症,与死亡率和发病率的增加有关.
- 药物诱导性病 (DIKD) 对AKI有显著的贡献,有限的研究集中在毒药物与置换疗法 (RRT) 的需要之间的联系上.
- 了解导致需要RRT的特定毒剂对于临床管理和预防策略至关重要.
研究的目的:
- 调查特定毒药物的使用与住院成年患者的替代疗法 (RRT) 开始之间的关联.
- 确定常见的毒药物,与急性护理环境中需要RRT相关.
主要方法:
- 进行了一项回顾性队列研究,涉及到被录取到高等学术中心的成人患者.
- 包括接受特定毒药物 (包括ACE抑制剂,万科米辛,皮佩拉西林/塔扎巴克坦和其他药物) 超过24小时的患者.
- 该研究分析了暴露于这些药物的患者中AKI的发生率和RRT的需求.
主要成果:
- 在86名患者中,25名 (29%) 患有AKI,15名 (17.4%) 需要RRT.
- 皮佩拉西林/塔扎巴克坦 (P=0.01),万科米辛 (P=0.02) 和血管激素转化酶抑制剂 (ACEI) (P=0.02) 与需要RRT显著相关.
- 用万科米辛,皮佩拉西林/塔扎巴克坦或ACEI治疗的住院患者显示需要RRT的可能性更高.
结论:
- 范科米辛,皮佩拉西林/塔扎巴克坦和ACE抑制剂的使用与住院患者增加替代疗法的需求有关.
- 识别患有药物诱导脏病风险的患者对于预防性干预来预防RRT进展至关重要.
- 需要进一步研究与这些药物诱导的损伤相关的特定机制和危险因素.
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