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Updated: Jan 8, 2026

Hydrogel Nanoparticle Harvesting of Plasma or Urine for Detecting Low Abundance Proteins
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使用铜纳米颗粒修饰的传感器在血液透析残留水和生物液中直接确定肌氨酸生物标志物

Gabriela Fonseca de Oliveira1, João Carlos de Souza1, José Luiz da Silva2

  • 1São Paulo State University (UNESP), Institute of Chemistry, Department of Analytical, Physical and Inorganic Chemistry, National Institute of Alternative Technologies for Detection, Toxicological Evaluation and Removal of Micropollutants and Radioactive Substances (INCT-DATREM), Prof. Francisco Degni St. 55, Araraquara 14800-060, São Paulo State, Brazil.

Analytical methods : advancing methods and applications
|December 23, 2025
PubMed
概括

一个使用铜纳米粒子在玻璃碳电极 (GCE-CuNPs) 上的新型电化学传感器提供了一种快速,廉价和可靠的方法来确定肌氨酸水平. 这一进步有助于通过分析各种体液样本来诊断功能障碍和其他健康问题.

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Drug Dosing in Renal Diseases: Measurement of Serum Creatinine Concentration and Clearance01:25

Drug Dosing in Renal Diseases: Measurement of Serum Creatinine Concentration and Clearance

In healthy individuals, serum creatinine levels remain stable due to a balance between its constant production—primarily from muscle metabolism—and renal excretion. Creatinine is freely filtered by the glomeruli, making it a valuable marker for estimating renal function. When the glomerular filtration rate (GFR) decreases, the kidneys can only eliminate less creatinine, causing serum levels to rise.Serum creatinine concentration is widely used to estimate creatinine clearance...
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Drug Dosing in Renal Diseases: Estimation of Glomerular Filtration Rate Based on Serum Creatinine Concentration01:28

Drug Dosing in Renal Diseases: Estimation of Glomerular Filtration Rate Based on Serum Creatinine Concentration

Glomerular filtration rate (GFR) can be estimated from serum creatinine using the modification of diet in renal disease (MDRD) formula or the chronic kidney disease–epidemiology collaboration (CKD–EPI) equation. Both methods are widely used in clinical practice to assess kidney function and guide treatment decisions.The MDRD equation does not require weight or height measurements and is normalized to the body surface area of 1.73 m², considered the average adult surface area.
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