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儿科炎症性肠病的疲劳:通过跨诊断和疾病重点因素解释
Maartje D Stutvoet1, Anouk Vroegindeweij1, Tessa Z Toonen2
1Department of Pediatrics, Wilhelmina Children's Hospital, University Medical Center Utrecht, Utrecht University, Utrecht, the Netherlands.
Journal of pediatric gastroenterology and nutrition
|December 23, 2025
概括
在患有炎症性肠病 (IBD) 的儿童中,严重疲劳是常见的,即使在缓解期. 睡眠,活动和心理健康等超诊断因素显著影响疲劳,而不是疾病因素.
科学领域:
- 儿科胃肠病学 儿科胃肠病学
- 临床心理学 临床心理学
- 生活质量研究 研究 生命质量研究
背景情况:
- 疲劳在儿科炎症性肠病 (IBD) 中非常普遍,即使在临床缓解期间也会持续.
- 这表明疾病本身以外的因素,如生活方式和心理影响 (跨诊断因素) 起着重要作用.
研究的目的:
- 为了确定IBD儿童严重疲劳的患病率.
- 研究疲劳与IBD特异性临床因素和更广泛的跨诊断因素的关联.
主要方法:
- 利用了来自PROactive队列的数据,其中包括127名患有IBD的儿童 (8-18岁).
- 使用儿科生活质量库存-多维疲劳量表来评估疲劳.
- 使用线性回归分析了相关性,检查了IBD临床数据,并对跨诊断因素验证了患者报告的结果措施.
主要成果:
- 29%的IBD儿童报告严重疲劳.
- 在IBD重点因素中,只有疾病活动和并发症与疲劳有显著的关联.
- 许多跨诊断因素,包括睡眠不足,体力活动不足,疼痛,焦虑,抑郁和生活满意度降低,与疲劳增加密切相关.
结论:
- 儿科IBD的疲劳与跨诊断因素比与疾病特异因素更密切相关.
- 综合性护理解决可修改的心理社会和生活方式因素对于减少疲劳和增强IBD儿童的福祉至关重要.
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