相关实验视频
Updated: Jan 8, 2026

09:36
Assessment of Child Anthropometry in a Large Epidemiologic Study
Published on: February 2, 2017
27.7K
在患有VACTERL的儿童中基于人口的癌症风险评估
Ji Yun Tark1, Alexander Renwick1,2, Giorgio Tettamanti3,4
1Section of Epidemiology and Population Sciences, Department of Medicine, Baylor College of Medicine, Houston, Texas, USA.
American journal of medical genetics. Part A
|December 23, 2025
概括
患有VACTERL (脊椎,门,心脏,气管,食道,脏,四肢缺陷) 的儿童患儿癌症,特别是胚胎瘤的风险明显更高. 这一发现表明,共同的发育路径可能会将这些疾病联系在一起.
科学领域:
- 儿科瘤学 儿科瘤学
- 发展生物学 发展生物学
- 流行病学 流行病学
背景情况:
- VACTERL (脊椎,门,心脏,气管食道,脏和四肢缺陷) 是一个非随机的出生异常的关联.
- 目前尚不清楚VACTERL与儿童癌症风险之间的关联.
研究的目的:
- 用基于人口的研究来评估被诊断为VACTERL的儿童的癌症风险.
- 为了将VACTERL治疗儿童的癌症发病率与未受影响儿童进行比较.
主要方法:
- 基于美国的基因重叠在异常和儿童癌症之间的研究 (GOBACK) 的数据分析.
- VACTERL定义为≥3个相关缺陷;使用了考克斯回归和卡普兰-梅尔分析.
- 在VACTERL病例和对照组之间比较癌症风险 (18岁之前).
主要成果:
- 在21,224,742个出生中,2288个符合VACTERL标准,8个患有癌症.
- 接受VACTERL治疗的儿童患癌症的风险增加了3.0倍 (HR=3.0,95% CI:1.5-6.0).
- 在VACTERL患者中,胚胎瘤特别增加 (HR=6.9,95% CI:2.9-16.5).
结论:
- VACTERL与儿童癌症的风险显著增加有关.
- 共同的发育或表观遗传因素可能会导致VACTERL和癌症.
- 需要进一步的研究来确定针对癌症监测的VACTERL子组.
相关概念视频
Cancer Prevention
7.6K
Several factors can increase the risk of cancer in an individual. About 50% of cancer cases can be prevented by adopting a healthy lifestyle, regular exercise, eating healthy, and following a modest cancer prevention diet. Epidemiological studies have consistently shown that populations with vegetable and fruit-rich diets have reduced the incidence of cancer. On the other hand, populations who have a diet rich in animal fat, red meat, junk food, or high calories are predisposed to cancer.
Some...
Some...
7.6K
Rous Sarcoma Virus (RSV) and Cancer
6.1K
Rous Sarcoma virus or RSV was discovered by F. Peyton Rous in the year 1911 as a filterable transmissible agent that could cause tumors in chickens. He won a Nobel Prize for this discovery in 1966. His experiments clearly demonstrated that some cancers could be caused by infectious agents and led to the discovery of many more cancer-causing viruses in animals as well as humans.
RSV is a retrovirus that contains two copies of a plus-strand RNA genome. Its genome consists of four main open...
RSV is a retrovirus that contains two copies of a plus-strand RNA genome. Its genome consists of four main open...
6.1K
Relative Risk
1.7K
Relative risk (RR) is a statistical measure commonly used in epidemiology to compare the likelihood of a particular event occurring between two groups. This metric is important for evaluating the relationship between exposure to a specific risk factor and the probability of a particular outcome. It plays a crucial role in medical research, public health studies, and risk assessment. Relative risk quantifies how much more (or less) likely an event is to occur in an exposed group compared to an...
1.7K
Mouse Models of Cancer Study
6.3K
Mice have long served as models for studying human biology and pathology because of their phylogenetic and physiological similarity with humans. They are also easy to maintain and breed in the laboratory, and hence, many inbred strains are now available for research. Studies on mice have contributed immeasurably to our understanding of cancer biology.
The development of transgenic, knockout, and knock-in mice has led to an exponential increase in their use as model organisms in research,...
The development of transgenic, knockout, and knock-in mice has led to an exponential increase in their use as model organisms in research,...
6.3K
Cancer
53.4K
Cancers arise due to mutations in genes involved in the regulation of cell division, which leads to unrestricted cell proliferation. Modern science and medicine have made great strides in the understanding and treatment of cancer, including eradicating cancer in some patients. However, there is still no cure for cancer. This is largely due to the fact that cancer is a large group of many diseases.
53.4K
Mutagenicity and Carcinogenicity
1.8K
Mutagenicity and carcinogenicity refer to the ability of drugs to cause genetic defects and induce cancer, respectively. The International Agency for Research on Cancer (IARC) classifies agents into four groups based on their carcinogenic potential. Group 1 agents are known human carcinogens; group 2A agents are probably carcinogenic to humans; group 3 agents lack data to support their role in carcinogenesis; and group 4 includes agents for which data support that they are not likely to be...
1.8K

