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通过开发一种非失活的固定化催化剂来解锁olefins的连续流动不对称化

Jorge Faiges¹, Nicola Zanda², Patricia Llanes³

¹Departament de Química Física i Inorgànica, Universitat Rovira i Virgili, C/ Marcel·lí Domingo 1, Tarragona, 43007, Spain.

Angewandte Chemie (International ed. in English)

|December 23, 2025

概括

本研究提出了一种简单的方法,用于将催化剂固定在树脂上,以进行连续不对称的化. 支持的催化剂在长时间内保持高效率和选择性,而无需金属漏,从而实现了对纯化合物的可持续生产.

科学领域:

催化剂是一种催化剂.
有机化学有机化学
材料科学材料科学材料科学

背景情况:

不对称的化 (AH) 对于产生反纯化合物至关重要.
在AH中使用的贵金属催化剂是昂贵的,它们的回收是具有挑战性的.
现有的支持连续流动AH的催化剂经常遭受停用和金属液,阻碍工业应用.

研究的目的:

开发一种简单有效的方法来固定基于的催化剂,用于连续流动的不对称化.
创建空气稳定,支持的催化剂,保持同质对应物的高性能.
解决工业AH工艺中的催化剂回收和浸出问题.

主要方法:

--硫化物 (Ir-P,S) 复合物的共价固定在聚烯树脂上.
在没有额外的合成步骤的情况下合成稳定于空气的功能化树脂.
固定催化剂在烯酸不对称化过程中的应用.

主要成果:

固定的Ir-P,S催化剂完全保留了同质催化剂的性能.
在连续流动的AH中成功地应用了具有高产量和选择性的多种类型的烯酸.
在长时间内保持持续的催化活性,没有观察到的失活或泄.
与批量反应相比,在低停留时间和降低压力的操作.

结论:

已经建立了一个简单的合成路线,用于强大的,不移动的AH催化剂.
开发的受支持的催化剂为工业连续流 AH.提供了可持续和实用的解决方案.
固定催化剂表现出卓越的稳定性,可重复使用性和性能,克服了以前方法的关键局限性.

关键词:

不对称的化.催化剂固定化催化剂固定化连续的流量流动连续的流动.和的价值和的价值在P,S-连体中,P,S-连体

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