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Updated: Jan 8, 2026

Mizoroki-Heck Cross-coupling Reactions Catalyzed by Dichloro{bis[1,1',1''-phosphinetriyltripiperidine]}palladium Under Mild Reaction Conditions

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基化物和多西兰的Zn介导交叉合

Pan Pan¹, Jingcao Li², Yan-Lin Zhang³

¹Biomass Oligosaccharides Engineering Technology Research Center of Anhui Province, School of Chemical and Material Engineering, Fuyang Normal University, Fuyang 236037, China.

The Journal of organic chemistry

|December 23, 2025

概括

一种新方法通过催化合成基,避免过渡金属和连接体. 这种高效的工艺可以从简单的前体中产生多种类型的基基基,用于进一步的化学修饰.

科学领域:

有机化学有机化学
有机金属化学有机金属化学
合成化学合成化学

背景情况:

基尼西兰是有机合成中的多功能构建块.
现有的基尼西兰合成方法通常需要过渡金属或特定的配体,限制了它们的实用性.
开发没有金属和配体的合成路径是非常可取的.

研究的目的:

报道了一种新的介导的基化的合成.
建立一个不含过渡金属和连接物的协议,用于基尼西兰制剂.
为了证明开发的方法的广泛适用性.

主要方法:

使用作为基化物和多西兰的合媒介.
采用一系列基化物和各种化,包括单化.
进行控制实验和密度函数理论 (DFT) 计算,以阐明反应机制.

主要成果:

在中等到优秀的产量中,成功合成了各种基基.
证明该方法与各种基板的兼容性.
识别一种S_N2类型的替代途径,其中涉及基中间体.

结论:

开发的协议提供了一个实用和一般的方法来合成alkynylsilanes.
该方法避免了对过渡金属和配体的需求,提供了一个更绿色的替代方案.
由此产生的基基基基基基基基基基基基基基基基基基基基基基基基基基基基基基基基基基基基基基基基基基基基基基基基基基基基基基基基基基基基基基基基基基基基基基基基基基基基基基基基基基基基基基基基基基基基基基基基基基基基基基基基基基基基基基基基基基基基基基基基基基基基基基基基基基基基基基基基基基基基基基基基基基基基基基基基基基基基基基基基基基基基基基基基基基基基基基基基基基基基基基基基基基基基基基基基基基基基基基基基基基基基基基基基基基基基基基基基基基基基基基基基基基基基基基基基基基基基基基基基基基基基基基基基基基基基基基基基基基基基基基基基基基基基基基基基基基基基基基基基基基基基基基基基基基基基基基基基基基基基基基基基基基基基基基基基

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