[在先进的初级开角青光眼中进行神经保护疗法]
D A Dorofeev1,2, I V Kozlova1, A I Vereshchagina3
1Krasnov Research Institute of Eye Diseases, Moscow, Russia.
Vestnik oftalmologii
|December 23, 2025
概括
与对照组相比,在先进的初级开角玻璃眼病 (POAG) 患者中,视野和视网膜神经纤维层厚度下降的速度较慢. 在稳定的眼内压力下定期服用是神经质蛋白保护益处的关键.
科学领域:
- 眼科医生 眼科 眼科
- 神经科学是一个神经科学.
背景情况:
- 主要开角青光眼 (POAG) 是不可逆转失明的主要原因.
- 晚期玻璃眼需要策略来减缓疾病的进展,并保持视觉功能.
- 正在研究神经保护剂,以补充传统的IOP管理.
研究的目的:
- 评估雷蒂纳拉对视觉分析仪结构和功能在先进POAG的长期影响.
- 为了评估定期服用雷蒂纳拉胺在减缓青光瘤进展方面的疗效.
- 为了确定是否Retinalamin在受控眼内压的患者中提供神经红蛋白保护性益处.
主要方法:
- 一项前性多中心队列研究,涉及56名患有晚期POAG的患者 (98只眼睛).
- 患者在两年内每三个月接受定期肌肉内注射Retinalamin (5毫克).
- 对照组接受了没有神经保护疗法的标准护理;所有患者都保持了稳定的眼内压力 (IOP).
主要成果:
- 与对照组 (1.65dB/年) 相比,Retinalamin组显示视野平均偏差 (MD) 的下降速度较慢 (0.98dB/年).
- 视网膜神经纤维层 (RNFL) 厚度在视网膜胺组中最小降低 (1.5微米/年),而对照组中更明显的降低 (3.0微米/年).
- 模式标准偏差 (PSD) 变化表明,视野恶化速度较慢在视网胺组.
结论:
- 长期,定期的雷蒂纳胺治疗对晚期POAG患者有益.
- 当IOP稳定且得到良好控制时,用Retinalamin进行神经联保护是有效的.
- 网红素治疗可以帮助维护视觉功能,并减缓晚期玻璃眼的结构损伤.
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