评估身体圆度指数作为牛皮风险预测的新型数字生物标志物:横截面研究
Pengfei Wen1, Xiaoyan Wang2, Xiaoxue Zhuo1
1Department of Dermatology, West China Hospital, Sichuan University, No. 37 Guoxue Alley, Wuhou District, Chengdu, 610041, China, 86 13982262622.
JMIR medical informatics
|December 23, 2025
概括
身体圆度指数 (BRI) 是比BMI或腰围 (WC) 更好地预测牛皮风险. 较高的BRI与增加的牛皮风险有关,这表明其用于早期检测和个性化管理.
科学领域:
- 皮肤病学 皮肤病学
- 代谢健康 代谢健康
- 生物统计学 生物统计学
背景情况:
- 牛皮是一种慢性炎症性皮肤疾病,与肥胖等代谢问题有关.
- 像BMI和腰围 (WC) 这样的传统措施可能不能完全表明代谢风险或身体脂肪分布.
- 身体圆度指数 (BRI) 是一种新的指标,整合了身高和腰部的测量,对牛皮的相关性尚未得到充分研究.
研究的目的:
- 评估身体圆度指数 (BRI) 作为皮风险评估的数字生物标志物.
- 为了比较BRI与牛皮的体重指数 (BMI) 和腰围 (WC) 的预测能力.
- 分析不同的人口和代谢子组之间的这些关联.
主要方法:
- 从国家健康和营养检查调查 (2003-2014) 中对13,798名成年人进行横截面分析.
- 牛皮病状况是自我报告的;人类测量指标 (BRI,BMI,WC) 被计算.
- 使用加权多变量后勤回归和受限立方线分析,并对共变量进行调整. 开发了一个名图表来评估预测贡献.
主要成果:
- 身体圆度指数 (BRI) 与牛皮风险有显著的线性关联 (或每单位增加1.11),表现优于BMI (或1.03) 和WC (或1.01).
- 在最高的BRI三位数中的个人患牛皮的风险增加了1.73倍.
- 关联在各种人口和代谢子组中保持一致,BRI通过名录分析被确定为最有影响力的预测因素.
结论:
- 身体圆度指数 (BRI) 与BMI和WC相比显示出与牛皮风险的优越和一致的关联.
- BRI显示了作为早期牛皮风险分层的数字生物标志物的潜力.
- 将BRI整合到临床工具中可以增强个性化的牛皮预防和管理策略.
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