与结肠缩相关的患病率,危险因素和死亡率:基于人口的病例控制研究
Roni Kankaristo1, Ilkka Helenius2,3, Susanna Heiskanen2
1Department of Paediatric Surgery, Orthopaedics and Traumatology, University of Turku, Turku University Hospital, Turku, Finland. rekank@utu.fi.
在芬兰,结肠形 (CA) 的患病率低且稳定. 孕产妇糖尿病是一个危险因素,但CA的存活率很高,超过97%.
科学领域:
- 儿科手术 儿科手术
- 遗传性缺陷 遗传性缺陷是一种先天性缺陷
- 流行病学 流行病学
背景情况:
- 结肠 (CA) 是一种罕见的先天性胃肠道形.
- 了解其患病率和相关风险因素对于临床管理和公共卫生至关重要.
- 关于癌症患病率和风险因素的先前研究,特别是在北欧人口中,是有限的.
研究的目的:
- 确定2004-2017年在芬兰的结肠形 (CA) 的全国流行率,死亡率和并发异常情况.
- 探索与CA相关的潜在的孕产妇和怀孕相关的风险因素.
- 评估研究期间CA患病率的趋势.
主要方法:
- 采用病例控制研究设计,从芬兰国家登记处确定了36例先天性CA病例.
- 病例的分类是基于使用ICD-9/ICD-10代码同时发生的异常.
- 分析了孕产妇的风险因素,根据居住时间和受孕时间对每个病例进行了五个对照对应.
主要成果:
- CA的总患病率为每1万例出生0.45,在2004-2017年期间没有观察到显著变化.
- 母亲糖尿病被确定为与CA相关的显著风险因素 (p=0.03).
- 一半的CA病例 (50%) 呈现多种先天性异常,而41.7%是孤立的.
结论:
- 结肠 (CA) 是芬兰罕见的疾病,患病率稳定.
- 尽管经常出现并发异常,但CA的整体存活率非常高,为97%.
- 孕产妇糖尿病是一种可改变的风险因素,需要在CA.方面进行进一步的研究.
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