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改变抗微生物药物处方模式,并在澳大利亚第三级中心进行Enterococcus faecalis感染性内心炎的实验室报告

Nilanthy Vigneswaran¹, Kyra Y L Chua², Sadid Khan^3,2

¹Monash Infectious Diseases, Monash Health, Clayton, VIC, Australia. nilanthy.vigneswaran@gmail.com.

European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology

|December 23, 2025

概括

对Enterococcus faecalis感染性内心炎 (EFIE) 的治疗,在指导方针变化之后,已经转向安比西林治疗方案. 青素的使用量减少,而 ceftriaxone 和 vancomycin 的使用量增加,突出显示了处方异质性.

科学领域:

传染性疾病传染性疾病
抗微生物药物管理委员会
临床药房临床药房

背景情况:

感染性内心炎 (EFIE) 治疗通常包括青素和一个协同作用的药物.
青素是安培素的持续输液替代品,但存在与 ceftriaxone 的协同效应问题.
实验室准则的转变 (CLSI到EUCAST) 影响了抗菌素敏感性报告和治疗选择.

研究的目的:

评估EFIE对抗微生物药物处方实践的变化.
评估不断变化的实验室指南对EFIE治疗的影响.
分析EFIE治疗结果与处方轮班的关系.

主要方法:

在墨尔本莫纳什健康 (2014-2022) 的回顾性研究.
包括成年患者 (≥18岁) 接受EFIE治疗.
评估了p < 0.05.05的不变关联.

主要成果:

分析了104名患有EFIE的患者.
在EUCAST实施后,基于白素的治疗方案显著增加 (64.3%至82.3%).
青素的使用量下降 (36.7%至8.1%),而 ceftriaxone 和 vancomycin 的使用量增加.
在初始EFIE治疗中使用安培或基尼林单一治疗减少了.

结论:

在EFIE抗菌药物处方中存在显著的异质性.
处方变化反映了不断变化的证据,指导方针的变化以及缺乏最终的RCT数据.
需要随机对照试验数据来完善EFIE治疗建议.

关键词:

处方抗微生物药物处方抗微生物药物菌 (Enterococcus faecalis) 是一种菌.传染性内心炎是一种感染性内心炎.实验室报告工作报告

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