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对含有2-MNG的血清对改善皮肤色调和多颜色化的有效性进行评估

Rui Li^1,2, Baiyu Li², Yang Chen²

¹La Roche Posay, L'Oréal Dermatological Beauty, L'Oréal China, Shanghai, 200040, China.

Dermatology and therapy

|December 23, 2025

概括

这项研究表明,含有2-mercaptonicotinoyl glycine (2-MNG) 的血清可以有效地减少多颜色和黑斑. 2-MNG血清改善了皮肤色调均性和亮度,具有良好的耐受性.

科学领域:

皮肤病学皮肤病学
化品科学化品科学
生物化学生物化学

背景情况:

超色素和不均的皮肤色调是全球普遍存在的问题,特别是在中国.
2-mercaptonicotinoyl glycine (2-MNG) 是一种创新的抗色素成分,其向的是黑色素前体,可以替代传统的铁酶抑制剂.
梅拉西尔 (Melasyl®) 是2-MNG的商业名称.

研究的目的:

为了评估含有2-MNG的血清在改善面部皮肤色调均性和减少多色素化的有效性.
评估2-MNG对黑色素指数 (MI) 和个别类型角度 (ITA°) 值的影响.
为了确定2-MNG血清的整体皮肤益处和耐受性.

主要方法:

在中国进行了两项临床研究.
研究1:一项随机对照的个体内研究,使用紫外线诱导的色素模型来评估4周的皮肤色素.
研究2:对42名女性进行的开放性研究,在56天内评估皮肤颜色和黑色素指数,包括停药后7天的随访.

主要成果:

2-MNG血清显著改善了ITA°值,MI和视觉皮肤颜色得分.
观察到皮肤亮度显著改善,面部黑色素含量和黑斑减少.
血清显示了保湿的好处,改善了纹的外观,并表现出良好的耐受性.

结论:

含有2-MNG的血清有效地降低了皮肤中的黑色素含量,从而显著改善了黑斑和皮肤亮化.
血清耐受性良好,适合敏感皮肤使用.
2-MNG提供了一种新的方法来管理多颜色障碍.

关键词:

这是一种2-mercaptonicotinoyl甘氨酸.超色素化疾病超色素化疾病皮肤色调不均的不均性

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