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在轻度认知障碍中半球失衡:多式脑网络的图形理论分析

Yi-Yan Sun^1,2, Jia-Jia Wu², Mou-Xiong Zheng³

¹School of Rehabilitation Science, Shanghai University of Traditional Chinese Medicine, Shanghai, China.

Annals of medicine

|December 23, 2025

概括

轻度认知障碍 (MCI) 亚型表现出明显的大脑横向化变化. 阿姆尼斯蒂克MCI涉及左半球功能网络解体,建议针对半球横向化进行有针对性的干预.

科学领域:

神经科学是一个神经科学.
认知科学认知科学
医疗成像医学成像

背景情况:

半球横向化对于认知处理至关重要.
在认知障碍的各个亚型和严重程度之间,大脑横向化的变化尚未得到充分理解.

研究的目的:

为了研究半球横向化大脑结构和功能之间的半球横向化差异,在无记忆性MCI (aMCI),无记忆性MCI (naMCI) 和健康对照组之间.
探索网络变化与认知表现之间的关系.

主要方法:

与104名参与者进行的病例控制研究 (47名MCI,27名MCI,30名对照).
为每个半球构建功能性和白质结构性大脑网络.
计算图形理论指标和结构功能合以评估跨组和半球间差异.

主要成果:

两个MCI组都显示左向小世界属性减少. aMCI患者左半球聚类系数和局部效率降低.
在患者中观察到左半球局部效率的侧面化中断和结构-功能合中右半球主导地位的丧失.
aMCI中的异常集中在边缘和多式联网中,而MMCI显示在执行控制网络中的扩散变化.

结论:

aMCI和MAMCI表现出截然不同的横向化异常模式.
aMCI的特点是左半球功能网络解体.
针对异常的半球横向化模式可能是一个治疗策略.

关键词:

大脑网络分析半球半球侧面化半球侧面化轻度的认知障碍轻度的认知障碍

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