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胃肠道HIV储存体的单细胞表征揭示了异构的细胞表型

Jackson J Peterson1, Shipra Chandel2, Katherine James2

  • 1Department of Microbiology and Immunology, University of North Carolina at Chapel Hill, Chapel Hill, United States of America.

The Journal of clinical investigation
|December 23, 2025
PubMed
概括

胃肠道是持久性HIV-1的港湾,在各种CD4T细胞亚型,特别是Th17和Treg17细胞中发现了病毒储存库. 基因表达分析揭示了血液和肠道T细胞之间的关键差异,为艾滋病毒的持续性提供了洞察力.

关键词:
艾滋病/艾滋病病毒/艾滋病病毒免疫学 免疫学 免疫学文字转录学 (Transcriptomics) 是一个学科.

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The human body harbors a vast and diverse viral community known as the human virome. The virome includes bacteriophages that infect bacteria, and eukaryotic viruses that infect human cells. Transient dietary and environmental viruses also contribute to this dynamic ecosystem. Estimates suggest the human body may contain on the order of 10¹³ viral particles, though abundance varies widely by body site and detection method.Comprehensive characterization of the virome has become possible only with...