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Updated: May 12, 2026

Semi-Targeted Ultra-High-Performance Chromatography Coupled to Mass Spectrometry Analysis of Phenolic Metabolites in Plasma of Elderly Adults
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从传统的泰国多草药增强剂开发功能性饮料:富含抗氧化剂的微囊和全面的次慢性毒性评估

Thammarat Kaewmanee1, Acharaporn Issuriya2, Piyapong Choochana3

  • 1Department of Food Science and Nutrition, Faculty of Science and Technology, Prince of Songkla University, Muang, Pattani, Thailand.

PloS one
|December 23, 2025
PubMed
概括

为Phy-Blica-O (PBO) 优化微封装增强了其抗氧化特性. 由此产生的Phy-Blica-D (PBD) 草药茶配方在小鼠研究中被证明是安全的,显示了功能成分商业化潜力.

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Toxicity Testing in Animals01:23

Toxicity Testing in Animals

Toxicity tests in animals are grounded on two main assumptions: first, the effects observed in laboratory animals can be extrapolated to humans, especially when adjusted for body surface area; second, high-dose exposure in animals is essential to identify potential human hazards from lower doses. This is based on the quantal dose-response concept, which faces the challenge of extrapolating results from relatively few test animals to much larger human populations. For example, a 0.01% incidence...