碳素的使用中断发烧发作 - 随机对照CARDIF试验
Claudia Weiß1,2, Alice Hucko1,2, Stephanie Müller-Ohlraun1
1NeuroCure Clinical Research Center (NCRC), Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Berlin, Germany.
PloS one
|December 23, 2025
概括
与安慰剂相比,碳素吸入并没有有效地阻止儿童发烧发作. 这项研究发现,在家中治疗发烧性发作时,碳素和氧气之间的发作终止率没有显著差异.
科学领域:
- 儿科 儿科 儿科
- 神经学 神经学
- 紧急医疗 紧急医疗
背景情况:
- 发烧性发作在儿童中很常见,可能是由发烧引起的高通风和低头引起的.
- 在临床前和个别儿科病例中,增加CO2部分压力对终止发烧发作有希望.
研究的目的:
- 为了评估家用碳素 (5%CO2加95%O2) 吸入的有效性和安全性,以阻止反复发烧发作.
- 在一项随机,双盲,交叉试验中,比较碳素与安慰剂 (100%氧) 的有效性.
主要方法:
- 卡迪夫试验招募了92名年龄在0.5~5.0岁的儿童,他们首次发烧发作.
- 使用了一个随机的,单心的,前性的,双盲的,安慰剂控制的交叉设计.
- 记录了家长报告的发作持续时间和不良事件;100%的氧气作为安慰剂对照.
主要成果:
- 在接受治疗的20名患有反复发烧发作的儿童中,碳素在5/15次发作中终止发作,而氧气在8/11次发作中终止发作 (p=0.11).
- 在患有多次发作的儿童中,碳素在3/6例中停止了发作,而氧气在5/6例中停止了发作.
- 家庭护理人员报告说,在准确确定停止方面存在挑战.
结论:
- 碳素吸入并没有证明在家庭环境中中断急性发烧的疗效优于安慰剂.
- 该研究强调了护理人员在家庭环境中评估发作持续时间和终止的困难.
- 可能需要进一步的研究来探索用于发烧性的替代家庭干预措施.
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