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相关概念视频

Dementia01:30

Dementia

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Dementia is a collective term for cognitive disorders primarily affecting memory, thinking, and reasoning. It is not a specific disease but a syndrome, with Alzheimer's disease being the most common cause, accounting for approximately 60-80% of cases. Other types include vascular dementia, Lewy body dementia, and frontotemporal dementia. Dementia affects millions worldwide, particularly older adults, though it is not a normal part of aging.
The progression of dementia is generally gradual....
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Alzheimer's Disease: Treatment01:22

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Alzheimer's Disease (AD), a neurodegenerative disorder, is pathologically identified by amyloid plaques and neurofibrillary tangles composed of tau protein. AD pharmacotherapy aims to manage cognitive symptoms, delay disease progression, and treat behavioral symptoms. The treatment is primarily symptomatic and palliative, with no definitive disease-modifying therapy available. Cholinesterase inhibitors, including donepezil (Aricept), rivastigmine (Exelon), and galantamine (Razadyne), are...
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Alzheimer's Disease: Overview01:26

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Alzheimer's Disease (AD) is a continually advancing neurodegenerative disorder, distinguished by escalating memory loss, cognitive dysfunction, and dementia. The disease unfolds in three stages: preclinical, mild cognitive impairment (MCI), and dementia. Its onset is insidious, and the progression gradual, with the cause not well explained by other disorders.
The clinical diagnosis of AD hinges on the presence of memory and other cognitive impairments. Biomarkers, such as changes in Aβ...
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Neurodegenerative disorders are progressive diseases that cause irreversible damage and loss to neurons in specific brain areas. Examples of these disorders include Parkinson's disease, Alzheimer's disease, Multiple Sclerosis (MS), and Amyotrophic Lateral Sclerosis (ALS). These disorders share characteristics such as proteinopathies, selective neuronal vulnerability, and a complex interplay between genetic and environmental factors. The primary therapeutic goal for these conditions is...
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相关实验视频

Updated: Jan 8, 2026

A Computerized Functional Skills Assessment and Training Program Targeting Technology Based Everyday Functional Skills
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技术与痴呆症 会议前会议

Adolfo M Garcia1,2,3, Franco Javier Ferrante4,5,6, Gonzalo Nicolás Pérez4,5,6

  • 1Cognitive Neuroscience Center (CNC), Universidad de San Andrés, Buenos Aires, Buenos Aires, Argentina.

Alzheimer's & dementia : the journal of the Alzheimer's Association
|December 23, 2025
PubMed
概括

数字语音评估可以检测认知衰退. 为全球多样化的人口本地化工具包检查仿生语言 (TELL) 应用程序解决了痴呆症检测中的健康不平等问题.

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科学领域:

  • 数字健康数字健康
  • 认知神经科学是一种认知神经科学.
  • 全球卫生公平性全球卫生公平性

背景情况:

  • 数字语音评估显示,对认知衰退和痴呆症的早期检测充满希望.
  • 现有的工具主要服务于英语国家,高收入国家,造成全球健康差距.
  • "检查真实语言的工具包" (TELL) 是为了解决这些不平等问题而开发的,重点关注低收入和中等收入国家.

研究的目的:

  • 概述了为拉丁美洲和非洲国家,特别是智利和肯尼亚本地化TELL应用程序的适应和挑战.
  • 为不同的语言,文化和技术环境完善数字语音测试工具.

主要方法:

  • 跨学科的团队合作定制TELL的界面,提示,数据采集,预处理,指标和可视化.
  • 应用程序文本被翻译成西班牙语和斯瓦希里语,使用人工智能和人类审查.
  • 通过文化特定和文化中立的途径选择了语音诱导刺激,并为视频会议和离线模式增强了数据收集.

主要成果:

  • 实施了五步音频预处理系统,以处理各种采集环境.
  • 针对西班牙语和斯瓦希利语的量身定制指标是使用语言不可知,语言特定,跨语言和多语言资源开发的.
  • 用户反指导了临床指标可视化的优化,突出了成功和需要改进的领域.

结论:

  • 语音测试技术的跨文化适应带来了重大障碍,解决方案和妥协.
  • 经验教训为优化全球服务不足地区数字评估提供了最佳实践.
  • 这项工作有助于全球更公平地获得认知健康技术.