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相关概念视频

Dementia01:30

Dementia

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Dementia is a collective term for cognitive disorders primarily affecting memory, thinking, and reasoning. It is not a specific disease but a syndrome, with Alzheimer's disease being the most common cause, accounting for approximately 60-80% of cases. Other types include vascular dementia, Lewy body dementia, and frontotemporal dementia. Dementia affects millions worldwide, particularly older adults, though it is not a normal part of aging.
The progression of dementia is generally gradual....
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Alzheimer's Disease: Treatment01:22

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Alzheimer's Disease (AD), a neurodegenerative disorder, is pathologically identified by amyloid plaques and neurofibrillary tangles composed of tau protein. AD pharmacotherapy aims to manage cognitive symptoms, delay disease progression, and treat behavioral symptoms. The treatment is primarily symptomatic and palliative, with no definitive disease-modifying therapy available. Cholinesterase inhibitors, including donepezil (Aricept), rivastigmine (Exelon), and galantamine (Razadyne), are...
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Alzheimer's Disease (AD) is a continually advancing neurodegenerative disorder, distinguished by escalating memory loss, cognitive dysfunction, and dementia. The disease unfolds in three stages: preclinical, mild cognitive impairment (MCI), and dementia. Its onset is insidious, and the progression gradual, with the cause not well explained by other disorders.
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Neurodegenerative disorders are progressive diseases that cause irreversible damage and loss to neurons in specific brain areas. Examples of these disorders include Parkinson's disease, Alzheimer's disease, Multiple Sclerosis (MS), and Amyotrophic Lateral Sclerosis (ALS). These disorders share characteristics such as proteinopathies, selective neuronal vulnerability, and a complex interplay between genetic and environmental factors. The primary therapeutic goal for these conditions is...
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相关实验视频

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A Computerized Functional Skills Assessment and Training Program Targeting Technology Based Everyday Functional Skills
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技术与痴呆症 会议前会议

Adolfo M Garcia1,2,3, Franco Javier Ferrante4,5,6, Gonzalo Nicolás Pérez4,5,6

  • 1Cognitive Neuroscience Center (CNC), Universidad de San Andrés, Buenos Aires, Buenos Aires, Argentina.

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PubMed
概括

数字语音评估可以检测认知能力下降,但通常仅限于英语使用者. 工具包检查 Lifelike Language (TELL) 应用程序适用于全球多样化的人口,解决智利和肯尼亚的语言和文化需求.

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科学领域:

  • 数字健康数字健康
  • 计算语言学计算语言学
  • 神经科学是一个神经科学.

背景情况:

  • 数字语音评估为早期发现认知衰退和痴呆症提供了具有成本效益的客观工具.
  • 现有的数字语音工具主要服务于英语发言,高收入人口,造成全球健康不平等.
  • 检查真实语言的工具包 (TELL) 是为了满足低收入和中等收入国家的独特需求而开发的.

研究的目的:

  • 概述了为拉丁美洲和非洲国家,特别是智利和肯尼亚本地化TELL应用程序的适应和挑战.
  • 为不同的语言,文化和技术背景完善数字语音评估工具.
  • 通过本地化的数字健康解决方案,提高认知衰退检测的全球可访问性.

主要方法:

  • 与当地研究人员和临床医生组成跨学科团队,以定制TELL的界面,提示,数据采集,预处理,指标和可视化.
  • 开发了一种使用人工智能和人类审查将应用程序内容翻译成西班牙语和斯瓦希里语的协议.
  • 实施了国家特定的定制,包括文化特定和文化中立的刺激选择,增强的数据收集方法 (视频会议,离线) 和五步音频预处理系统.

主要成果:

  • 成功地将TELL应用程序 (v.2.0) 进行本地化,用于智利和肯尼亚,并将内容翻译成西班牙语和斯瓦希里语.
  • 开发了量身定制的指标,整合了语言不可知,语言特定,跨语言和多语言资源.
  • 增强数据收集和预处理能力,以适应各种环境和本地需求,包括离线模式和人工智能驱动的音频调整.

结论:

  • 数字语音测试技术的跨文化适应涉及重大障碍,需要创新的解决方案和妥协.
  • 经验教训为全球服务不足地区简化数字评估提供了最佳实践.
  • 本地化的TELL应用程序展示了一条通往全球认知健康监测更公平的途径.