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相关概念视频

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Dementia is a collective term for cognitive disorders primarily affecting memory, thinking, and reasoning. It is not a specific disease but a syndrome, with Alzheimer's disease being the most common cause, accounting for approximately 60-80% of cases. Other types include vascular dementia, Lewy body dementia, and frontotemporal dementia. Dementia affects millions worldwide, particularly older adults, though it is not a normal part of aging.
The progression of dementia is generally gradual....
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Alzheimer's Disease (AD), a neurodegenerative disorder, is pathologically identified by amyloid plaques and neurofibrillary tangles composed of tau protein. AD pharmacotherapy aims to manage cognitive symptoms, delay disease progression, and treat behavioral symptoms. The treatment is primarily symptomatic and palliative, with no definitive disease-modifying therapy available. Cholinesterase inhibitors, including donepezil (Aricept), rivastigmine (Exelon), and galantamine (Razadyne), are...
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Alzheimer's Disease (AD) is a continually advancing neurodegenerative disorder, distinguished by escalating memory loss, cognitive dysfunction, and dementia. The disease unfolds in three stages: preclinical, mild cognitive impairment (MCI), and dementia. Its onset is insidious, and the progression gradual, with the cause not well explained by other disorders.
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Neurodegenerative disorders are progressive diseases that cause irreversible damage and loss to neurons in specific brain areas. Examples of these disorders include Parkinson's disease, Alzheimer's disease, Multiple Sclerosis (MS), and Amyotrophic Lateral Sclerosis (ALS). These disorders share characteristics such as proteinopathies, selective neuronal vulnerability, and a complex interplay between genetic and environmental factors. The primary therapeutic goal for these conditions is...
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技术与痴呆症 会议前会议

Stephanie Ruth Young1, Julia Yoshino-Benavente1, Richard C Gershon1

  • 1Northwestern University Feinberg School of Medicine, Chicago, IL, USA.

Alzheimer's & dementia : the journal of the Alzheimer's Association
|December 23, 2025
PubMed
概括

升级的MyCog认知查工具在初级保健中对老年人显示出高可靠性和有效性. 改进的可用性并没有损害其心理测量特性,支持其继续用于早期认知障碍检测的临床使用.

科学领域:

  • 老年学是一门学科.
  • 认知科学 认知科学
  • 医疗信息学 医疗信息学

背景情况:

  • 在65岁以上的成年人中,早期发现认知障碍 (CI) 是至关重要的,但初级保健机构只能识别不到一半的受影响患者.
  • MyCog应用程序是NIH资助的基于平板电脑的认知选器,可以与电子健康记录集成,以帮助早期发现CI和决策支持.
  • 来自临床网站 (西北医学,树街健康,接入社区健康网络) 的反导致了MyCog应用程序的用户体验和界面的显著改进.

研究的目的:

  • 通过对升级的MyCog应用程序的构造验证提供证据.
  • 讨论升级的MyCog应用程序在临床环境中的可用性影响.
  • 为了评估增强的MyCog认知选器的心理测量特性.

主要方法:

  • 使用升级的MyCog的社区样本 (n=200,平均年龄=73) 与使用原始MyCog的年龄匹配样本进行了比较.
  • 使用确认因素分析来评估内部一致性和构造有效性.
  • 贝叶斯差异性项目功能分析评估了原始MyCog和MyCog 2.0.0之间的等价性.

主要成果:

  • 在执行功能 (rsb=.92) 和情节性记忆测试 (ωt=.84) 中发现了高内部一致性.
  • 一个双因素模型表现出很好的匹配,表明测试测量相关但不同的结构,优于一个单因素模型.

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  • 两种版本之间没有观察到对情节性记忆或执行功能准确性的差异性项目功能;然而,对五个执行功能项目的响应时间有所不同.

    • 结论:

    • 这些发现支持升级的MyCog作为适合老年人使用的可靠和有效的自我管理认知选器.
    • MyCog应用程序的可用性改进并没有影响其心理测量有效性,证实其适合继续临床使用.
    • 计划对MyCog应用程序进行进一步的临床验证研究.