Jove
Visualize
联系我们
JoVE
x logofacebook logolinkedin logoyoutube logo
关于 JoVE
概览领导团队博客JoVE 帮助中心
作者
出版流程编辑委员会范围与政策同行评审常见问题投稿
图书馆员
用户评价订阅访问资源图书馆顾问委员会常见问题
研究
JoVE JournalMethods CollectionsJoVE Encyclopedia of Experiments存档
教育
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab Manual教师资源中心教师网站
使用条款与条件
隐私政策
政策

相关概念视频

Dementia01:30

Dementia

482
Dementia is a collective term for cognitive disorders primarily affecting memory, thinking, and reasoning. It is not a specific disease but a syndrome, with Alzheimer's disease being the most common cause, accounting for approximately 60-80% of cases. Other types include vascular dementia, Lewy body dementia, and frontotemporal dementia. Dementia affects millions worldwide, particularly older adults, though it is not a normal part of aging.
The progression of dementia is generally gradual....
482
Alzheimer's Disease: Treatment01:22

Alzheimer's Disease: Treatment

744
Alzheimer's Disease (AD), a neurodegenerative disorder, is pathologically identified by amyloid plaques and neurofibrillary tangles composed of tau protein. AD pharmacotherapy aims to manage cognitive symptoms, delay disease progression, and treat behavioral symptoms. The treatment is primarily symptomatic and palliative, with no definitive disease-modifying therapy available. Cholinesterase inhibitors, including donepezil (Aricept), rivastigmine (Exelon), and galantamine (Razadyne), are...
744
Alzheimer's Disease: Overview01:26

Alzheimer's Disease: Overview

1.6K
Alzheimer's Disease (AD) is a continually advancing neurodegenerative disorder, distinguished by escalating memory loss, cognitive dysfunction, and dementia. The disease unfolds in three stages: preclinical, mild cognitive impairment (MCI), and dementia. Its onset is insidious, and the progression gradual, with the cause not well explained by other disorders.
The clinical diagnosis of AD hinges on the presence of memory and other cognitive impairments. Biomarkers, such as changes in Aβ...
1.6K
Parkinson's Disease: Overview01:15

Parkinson's Disease: Overview

1.7K
Neurodegenerative disorders are progressive diseases that cause irreversible damage and loss to neurons in specific brain areas. Examples of these disorders include Parkinson's disease, Alzheimer's disease, Multiple Sclerosis (MS), and Amyotrophic Lateral Sclerosis (ALS). These disorders share characteristics such as proteinopathies, selective neuronal vulnerability, and a complex interplay between genetic and environmental factors. The primary therapeutic goal for these conditions is...
1.7K

您也可能阅读

相关文章

通过共同作者、期刊和引用图与本文相关的文章。

排序
Same author

Instrumental Activities of Daily Living in Older Adults with Epilepsy: A Cross-Sectional and Longitudinal Multicenter Study.

medRxiv : the preprint server for health sciences·2026
Same author

A multiverse analysis of the logical memory test and plasma biomarkers of Alzheimer's disease.

Cortex; a journal devoted to the study of the nervous system and behavior·2026
Same author

Alzheimer's disease neuroimaging signature aids identification of cognitive impairment in older adults with early-onset epilepsy.

medRxiv : the preprint server for health sciences·2026
Same author

The IMPACT epilepsy Consortium: Exploring social drivers of health in epilepsy care to advance solution based initiatives.

Epilepsy & behavior : E&B·2026
Same author

Utility of the ADAS-Cog as a Cognitive Screening Tool in Older Adults with Epilepsy: A Multicenter Cohort Study.

medRxiv : the preprint server for health sciences·2026
Same author

Evaluating the interpretability of clinical speech AI models: Lessons from two user studies.

Computer speech & language·2026

相关实验视频

Updated: Jan 8, 2026

A Computerized Functional Skills Assessment and Training Program Targeting Technology Based Everyday Functional Skills
07:31

A Computerized Functional Skills Assessment and Training Program Targeting Technology Based Everyday Functional Skills

Published on: February 13, 2020

7.3K

技术与痴呆症 会议前会议

Madeline R Hale1,2, Deling He3, Rebecca E Langhough4,5,6

  • 1Department of Communication Sciences and Disorders, University of Wisconsin-Madison, Madison, WI, USA.

Alzheimer's & dementia : the journal of the Alzheimer's Association
|December 23, 2025
PubMed
概括

在故事回忆中的语音暂停分析可以检测早期阿尔茨海默病 (AD). 轻度认知障碍 (MCI) 患者与认知无障碍 (CU) 个体相比,表现出更长的暂停和更短的言语持续时间,表明潜在的AD生物标志物.

更多相关视频

The Immersive Cleveland Clinic Virtual Reality Shopping Platform for the Assessment of Instrumental Activities of Daily Living
08:36

The Immersive Cleveland Clinic Virtual Reality Shopping Platform for the Assessment of Instrumental Activities of Daily Living

Published on: July 28, 2022

4.3K
Transcranial Pulse Stimulation for Alzheimer's Patients
06:08

Transcranial Pulse Stimulation for Alzheimer's Patients

Published on: April 4, 2025

2.0K

相关实验视频

Last Updated: Jan 8, 2026

A Computerized Functional Skills Assessment and Training Program Targeting Technology Based Everyday Functional Skills
07:31

A Computerized Functional Skills Assessment and Training Program Targeting Technology Based Everyday Functional Skills

Published on: February 13, 2020

7.3K
The Immersive Cleveland Clinic Virtual Reality Shopping Platform for the Assessment of Instrumental Activities of Daily Living
08:36

The Immersive Cleveland Clinic Virtual Reality Shopping Platform for the Assessment of Instrumental Activities of Daily Living

Published on: July 28, 2022

4.3K
Transcranial Pulse Stimulation for Alzheimer's Patients
06:08

Transcranial Pulse Stimulation for Alzheimer's Patients

Published on: April 4, 2025

2.0K

科学领域:

  • 神经学 神经学
  • 语音语言病理学 语言病理学
  • 生物标志物 生物标志物

背景情况:

  • 微妙的语音特征,包括暂停,对阿尔茨海默病 (AD) PET生物标志物敏感.
  • 之前的研究表明,Cookie Theft (CT) 图片描述中的沉默暂停区分了认知正常 (CU) 和认知受损的个体.
  • 目前的研究调查了暂停检测在故事回忆 (SR) 任务中的实用性.

研究的目的:

  • 检查基于声学的静音暂停分析在区分轻度认知障碍 (MCI) 患者和使用故事回忆任务的CU患者之间的有效性.
  • 为了将语音暂停指标与PET生物标志物 (粉样蛋白/蛋白),神经心理测试结果和整体认知状态相关联.

主要方法:

  • 来自威斯康星州阿尔茨海默氏症预防登记处 (WRAP) 和威斯康星州阿尔茨海默氏症研究中心 (WADRC) 的50名参与者 (25 MCI, 25 CU) 的倾向得分匹配.
  • 延迟故事回忆音频 (逻辑记忆/Craft Story) 经过处理,使用 MATLAB 语音暂停分析提取无声暂停 (>80ms).
  • 统计分析包括威尔科克森签名等级测试,斯皮尔曼相关性,后勤回归和ROC分析,以比较暂停指标和认知状态.

主要成果:

  • 认知正常 (CU) 参与者表现出更多的故事回忆 (SR) 持续时间 (p=0.001,r=0.622).
  • 轻度认知障碍 (MCI) 的参与者表现出更长的平均休息时间 (p=0.0317,r=0.374) 和更高的休息百分比 (p=0.045,r=0.342).
  • 总SR持续时间是认知状态的显著预测指标 (OR=0.93,CI=0.89-0.97,AUC=0.76),超过CT分析 (AUC=0.57).

结论:

  • 与CU参与者相比,患有MCI的个人产生了较短的SR样本,停顿的百分比和持续时间更大.
  • 在SR中,较短的言语持续时间与较高的粉样β水平相关,这表明与AD病理学的联系.
  • 基于声学的自动化暂停分析显示,它是阿尔茨海默病的早期诊断标记,值得在不同人群中进一步调查.