与SARS-CoV-2感染相关的新发甲状腺疾病风险增加:一项为期4.5年的观察性研究
Shiv Mehrotra-Varma1, Roham Hadidchi1, Sonya Henry1
1Department of Radiology, Montefiore Health System and Albert Einstein College of Medicine, Bronx, NY, USA.
The Journal of clinical endocrinology and metabolism
|December 23, 2025
概括
在住院和非住院的患者中,COVID-19感染增加了发展新的甲状腺功能障碍的风险,包括甲状腺功能低下和甲状腺功能过高,在住院和非住院患者中. 推在COVID-19后恢复后加强甲状腺问题的查.
科学领域:
- 内分泌学 在内分泌学.
- 传染性疾病 传染性疾病
- 公共卫生 公共卫生
背景情况:
- 甲状腺疾病是急性SARS-CoV-2感染的已知并发症.
- COVID-19对甲状腺功能的长期影响需要进一步调查.
研究的目的:
- 评估COVID-19后新出现的甲状腺功能障碍的长期风险.
- 为了比较住院,非住院COVID-19患者和对照组之间的风险.
主要方法:
- 使用蒙特菲奥雷医疗系统电子健康记录进行的回顾性队列研究.
- 包括住院COVID-19,非住院COVID-19,当代COVID阴性和历史控制组.
- 使用考克斯回归与反向概率加权 (IPW) 和倾向得分匹配进行分析.
主要成果:
- 与对照人群相比,住院COVID-19患者的甲状腺疾病 (HR=2.11),甲状腺功能低下 (HR=2.02),甲状腺功能增强 (HR=2.31) 和其他甲状腺问题 (HR=2.27) 的风险明显更高.
- 非住院COVID-19患者在所有类别的甲状腺疾病中也存在高风险.
- 敏感性分析证实了这些发现,尽管与历史对照相比,风险减弱了.
结论:
- SARS-CoV-2 感染与各种新发的甲状腺疾病的发病率增加有关.
- 从COVID-19中恢复过来的个人可能会从增加的甲状腺功能障碍查中受益.
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