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相关概念视频

Dementia01:30

Dementia

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Dementia is a collective term for cognitive disorders primarily affecting memory, thinking, and reasoning. It is not a specific disease but a syndrome, with Alzheimer's disease being the most common cause, accounting for approximately 60-80% of cases. Other types include vascular dementia, Lewy body dementia, and frontotemporal dementia. Dementia affects millions worldwide, particularly older adults, though it is not a normal part of aging.
The progression of dementia is generally gradual....
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Alzheimer's Disease (AD), a neurodegenerative disorder, is pathologically identified by amyloid plaques and neurofibrillary tangles composed of tau protein. AD pharmacotherapy aims to manage cognitive symptoms, delay disease progression, and treat behavioral symptoms. The treatment is primarily symptomatic and palliative, with no definitive disease-modifying therapy available. Cholinesterase inhibitors, including donepezil (Aricept), rivastigmine (Exelon), and galantamine (Razadyne), are...
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Alzheimer's Disease (AD) is a continually advancing neurodegenerative disorder, distinguished by escalating memory loss, cognitive dysfunction, and dementia. The disease unfolds in three stages: preclinical, mild cognitive impairment (MCI), and dementia. Its onset is insidious, and the progression gradual, with the cause not well explained by other disorders.
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Neurodegenerative disorders are progressive diseases that cause irreversible damage and loss to neurons in specific brain areas. Examples of these disorders include Parkinson's disease, Alzheimer's disease, Multiple Sclerosis (MS), and Amyotrophic Lateral Sclerosis (ALS). These disorders share characteristics such as proteinopathies, selective neuronal vulnerability, and a complex interplay between genetic and environmental factors. The primary therapeutic goal for these conditions is...
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技术与痴呆症 会议前会议

Marialy Salinas Valdez1, Samantha Gates1, Vanessa M Young2,3,4

  • 1Glenn Biggs Institute for Alzheimer's and Neurodegenerative Diseases, University of Texas Health Science Center, San Antonio, TX, USA.

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概括

数字调查显示,西班牙裔/拉丁裔成年人轻度认知障碍 (MCI) 检测的微妙差异. 在MCI中,较低的调查完成率和较长的完成时间可能表明早期的功能变化.

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科学领域:

  • 老年学是一门学科.
  • 神经科学是一个神经科学.
  • 公共卫生 公共卫生

背景情况:

  • 阿尔茨海默病和相关痴呆症 (AD/ADRD) 不成比例地影响服务不足的人群,包括西班牙裔/拉丁裔成年人.
  • 这一群人群的认知和功能变化仍未得到充分研究.
  • 在COMPADRE-CART研究中,利用家庭技术监测西班牙裔/拉丁裔成年人的健康和活动.

研究的目的:

  • 为了检查认知不受损 (CU) 和轻度认知障碍 (MCI) 的西班牙裔/拉丁裔成年人之间的家庭活动模式的差异.
  • 为了在基准时比较CU和MCI组之间的每周数字调查完成指标和响应.

主要方法:

  • 招募了来自南德克萨斯州的62岁以上的西班牙裔/拉丁裔参与者.
  • 使用家庭技术,包括室内传感器和手腕穿戴的动作计来监控活动.
  • 通过每周的数字调查 (Qualtrics) 和临床评估 (UDS 3) 收集的自我报告数据.

主要成果:

  • 在CU和MCI组之间没有观察到日常活动模式 (步骤,睡眠,在家外的时间) 的显著差异.
  • 患有MCI的参与者表现出较低的每周调查完成率和更长的调查完成时间.
  • MCI 组报告了更高的疼痛水平,但其他自我报告的健康事件在各组中都相似.

结论:

  • 每周数字问卷指标显示,在患有MCI的西班牙裔/拉丁裔成年人中,有潜力检测微妙的功能差异.
  • 对这些数字指标的纵向监测可以预测未来的认知衰退.