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阿尔茨海默氏症成像联盟

Maria Franquesa-Mullerat1, Alejandra O Morcillo-Nieto1,2, José Enrique Arriola-Infante1,2

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概括
此摘要是机器生成的。

唐氏综合征 (DS) 患者表现出改变的大脑输液,可以通过MRI早期检测到. 这些变化类似于阿尔茨海默病 (AD) 模式,与AD生物标志物相关,突出了早期检测的潜力.

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科学领域:

  • 神经成像是一种神经成像.
  • 神经退行性疾病 神经退行性疾病
  • 遗传学 是一个遗传学.

背景情况:

  • 唐氏综合征 (DS) 个体由于21号染色体的三倍化,患阿尔茨海默病 (AD) 的风险较高.
  • 大脑缩在DS中被研究,但大脑血流 (CBF) 变化被理解得更少.
  • 这项研究使用MRI调查了沿AD连续性沿DS的早期CBF变化.

研究的目的:

  • 使用伪连续动脉旋转标记 (pCASL) 探索唐氏综合征 (DS) 的成年人早期脑血流 (CBF) 改变的MRI.
  • 将DS中的CBF模式与散发性阿尔茨海默病 (sAD) 的CBF模式进行比较.
  • 在DS中调查CBF,临床阶段和AD生物标志物之间的关系.

主要方法:

  • 截面MRI分析32个euploid认知无损 (eCU),37个DS和24个sAD个体.
  • 使用伪连续动脉旋转标记 (pCASL) 的3T-MRI进行CBF测量.
  • 分析了年龄,性别,临床阶段和AD生物标志物 (CSF Aβ1-42/Aβ1-40,pTau-181,海马体积) 对CBF的影响.

主要成果:

  • 与年龄相关的CBF下降是特定区域的:ecu中的前额外,ds中的顶额,sAD中的.
  • 在DS中,低输液从 temporoparietal 进展到前部区域,并出现症状,模仿sAD.
  • 时间关节性CBF与AD生物标志物相关,特别是海马体积,并且与无症状和症状的DS区分开来.

结论:

  • 大脑输液在AD连续性沿着DS的成年人显著改变,在临床症状之前可检测到.
  • 在症状阶段的DS中,低输液类似于sAD模式,影响着 temporoparietal和frontal区域.
  • pCASL显示了检测DS早期功能变化的潜力,有助于理解这一高风险组的AD进展.