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阿尔茨海默氏症成像联盟

Emma M Coomans1,2, Ruben Smith3,4, Daria Pawlik5

  • 1Department of Neurology, Alzheimer Center Amsterdam, Amsterdam Neuroscience, Vrije Universiteit Amsterdam, Amsterdam, Netherlands.

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概括
此摘要是机器生成的。

高龄和男性性别与阿尔茨海默病中较低的Tau-PET吸收有关,这是由于tau纠密度降低. -PET准确地反映了这种病理,尽管老年男性的敏感性可能会下降.

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科学领域:

  • 神经成像和神经病理学
  • 阿尔茨海默氏症疾病研究研究
  • 生物标志物开发 生物标志物开发

背景情况:

  • 高龄和男性性别独立地与症状性阿尔茨海默病 (AD) 中的Tau-PET摄入量减少有关.
  • 了解这些人口统计学对病理学影响的PET与神经病理学相关性对于准确的诊断和研究至关重要.

研究的目的:

  • 用独立的PET和尸检队伍调查年龄,性别和tau-PET吸收之间的关系.
  • 检查PET与tau-PET的神经病理学对应的研究,以及死后的布拉克分期和纠结密度,分年龄和性别分层.

主要方法:

  • 对680名患有MCI或痴呆症的粉素阳性参与者的[18F]flortaucipir-PET数据的分析.
  • 分析947例尸检中神经病理学数据 (布拉克分期,纠结密度) 的分析,CERAD评分为中度至频繁.
  • 在84个病例中,PET与尸体解剖的直接相关性,评估Tau-PET对跨年龄和性别层的Braak-V/VI病理的准确性.

主要成果:

  • 独立的PET和尸检分析证实,年龄较大和男性性别与较低的Tau-PET摄入量和Braak-V/VI神经病变的流行率有关.
  • 在尸体解剖案例中,年龄较大,但不是男性性别,与布拉克-V/VI病理病理患者中较低的纠密度相关.
  • PET-to-autopsy分析显示,Tau-PET对Braak-V/VI tau具有很高的特异性,但随着年龄的增长和男性的敏感性下降,与较低的纠密度一致.

结论:

  • 在老年人和男性中观察到的较低的Tau-PET吸收和患病率是由解剖时降低的tau纠密度解释的.
  • 陶-PET成像显示出与死后纠密度的强烈相关性,验证了其作为生物标志物的实用性.
  • 这些发现强调,虽然Tau-PET反映了tau病理,但由于结密度的变化,其在检测高级Braak阶段的灵敏度可能在老年男性中较低.