基础科学和病原发生学
Susan K Rohde1,2,3,4, Maruelle C Luimes2,3,4, Annemieke J M Rozemuller5,6
1Amsterdam UMC, location VUmc, Amsterdam, Netherlands, Amsterdam, Netherlands, Amsterdam, Netherlands.
Alzheimer's & dementia : the journal of the Alzheimer's Association
|December 23, 2025
概括
在百岁老人中,阿尔茨海默病的神经病理变化 (ADNC) 和初级与年龄相关的病 (PART) 显示重叠的模式,与年轻人不同. 然而,特定大脑区域的粉样β (Aβ) 和病态与认知能力下降相关.
科学领域:
- 神经病理学神经病理学
- 神经科学是一个神经科学.
- 衰老研究研究 衰老研究
背景情况:
- 阿尔茨海默病的神经病理变化 (ADNC) 和初级与年龄相关的病 (PART) 呈现出不同的海马病理模式.
- 与ADNC相比,PART是一种粉样β (Aβ) 独立的陶病,CA2/CA1高酸化陶 (pTau) 比率较高.
- 这些明显的模式在极端年龄的持续性和它们与百岁老人的认知相关性仍然不清楚.
研究的目的:
- 为了调查不同的海马pTau分布是否会持续到极端的年龄.
- 检查海马Aβ和pTau分布与百岁老人的认知功能之间的相关性.
- 为了比较百岁老人的神经病理模式与ADNC与PART.
主要方法:
- 在8个海马和副海马子区域的量化Aβ和pTau负担在112个百岁老人,11个AD和7个PART病例中.
- 在满足PART与ADNC标准的百岁老人中比较CA2/CA1-pTau比率.
- 使用13个神经心理测试评估认知表现,并采用强大的线性回归来将病理与认知联系起来.
主要成果:
- 百岁老人与PART的CA2/CA1-pTau比率与ADNC的人相似,与年轻人不同.
- 在百岁老人中,CA2/CA1-pTau比率与Aβ负担,Thal阶段或Braak阶段无关.
- 较高的海马Aβ负担和准海马pTau负担与较低的认知表现有关.
结论:
- 在最老的老年人中,PART和ADNC的传统决定因素差异较小.
- 患有ADNC的百岁老人可能会表现出Aβ积累与PART类型的pTau模式,而PART病例可能并不总是显示PART类型的pTau模式.
- 海马体的Aβ负担和海马体外的pTau负担与认知能力下降有关,这表明亚区域的脆弱性.
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