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Alzheimer's Disease: Overview01:26

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Alzheimer's Disease (AD) is a continually advancing neurodegenerative disorder, distinguished by escalating memory loss, cognitive dysfunction, and dementia. The disease unfolds in three stages: preclinical, mild cognitive impairment (MCI), and dementia. Its onset is insidious, and the progression gradual, with the cause not well explained by other disorders.
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DefinitionComputed Tomography (CT) of the genitourinary (GU) tract is a non-invasive imaging modality that utilizes X-rays and computer processing to generate detailed cross-sectional images of the urinary system, encompassing the kidneys, ureters, bladder, and adjacent structures such as the adrenal glands.PurposeCT scans of the GU tract serve several diagnostic and therapeutic purposes, including:Diagnosis of Urinary Tract Diseases: Detects kidney stones, tumors, cysts, and congenital...
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Introduction:Magnetic Resonance Imaging, or MRI, can include a specialized imaging technique of the urinary system known as Magnetic Resonance Urography (MRU). This radiation-free technique uses strong magnetic fields and radio waves to produce detailed images with the help of a computer. MRU is particularly effective for visualizing fluid-filled structures like the kidneys, ureters, and bladder.Applications of MRI in the Genitourinary SystemKidneys and Ureters: MRI detects tumors, cysts,...
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Brain imaging technologies provide critical insights into both the structure and function of the human brain, enabling medical professionals and researchers to diagnose, study, and treat neurological disorders or psychiatric disorders more effectively.
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Positron Emission Tomography (PET) is a medical imaging technique that provides crucial insights into the body's physiological functions at a molecular level. It is an indispensable resource for diagnosing, staging, and monitoring various illnesses, notably cancer, neurological disorders, and cardiovascular conditions.
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Hybrid PET/MRI Imaging of Alzheimer's Disease Based on 18F-AV-1451
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阿尔茨海默氏症成像联盟

Michel J Grothe1, Linda Zhang1, Francisco J López-González1

  • 1CIEN Foundation, Reina Sofia Alzheimer Center, ISCIII, Madrid, Madrid, Spain.

Alzheimer's & dementia : the journal of the Alzheimer's Association
|December 23, 2025
PubMed
概括

边缘年龄相关的TDP-43脑病变与海马硬化症的神经病理变化在MRI上显示大脑全缩模式,延伸到海马之外. 这种签名可能有助于在体内诊断LATE-NC.

科学领域:

  • 神经病理学神经病理学
  • 神经成像是一种神经成像.
  • 老年医学 老年医学

背景情况:

  • 边缘性与年龄相关的TDP-43脑病变神经病变 (LATE-NC) 经常与阿尔茨海默氏病的神经病变 (ADNC) 同时发生.
  • 与LATE-NC相关的海马硬化 (HS) 导致独立于AD的记忆缺陷.
  • 虽然FDG-PET和MRI研究在HS中发现了temporo-limbic签名和海马缩,但LATE-NC相关的HS中大脑全缩模式需要进一步描述.

研究的目的:

  • 描述与LATE-NC和HS相关的基于MRI的全脑缩模式.
  • 调查这个模式是否与没有HS的AD不同.
  • 探索HS严重程度与区域大脑体积之间的关系.

主要方法:

  • 研究了84名痴呆症患者,进行了详细的神经病理学评估和死前3T-MRI.
  • 使用二进制和分阶段方案评估ADNC,LATE-NC和HS.
  • 分析了52个大脑区域的MRI数据,使用基于ROI的分析,将解剖病例与1032名健康对照进行了比较.

主要成果:

  • 患有LATE-NC+HS和AD-noHS的痴呆病例表现出类似的大脑全缩,最明显的是在中部/前部部和侧部部-部区域.
  • 与AD-noHS相比,LATE-NC+HS病例在海马体,杏仁体,极,胰岛和轨道前皮层中显著增加了缩.

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  • 在所有解剖病例中,在HS严重程度阶段和门边缘缩模式之间发现了强烈的相关性.

    • 结论:

    • 与LATE-NC相关的HS与延伸到海马体之外的体内MRI缩模式有关.
    • 这种扩展性缩涉及受到LATE-NC.中TDP-43病理影响的temporo-limbic皮质区域.
    • 识别的MRI特征可能会改善临床检测LATE-NC相关的HS.