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阿尔茨海默氏症成像联盟

Mahir Tazwar1, Arnold M Evia2, Abdur Raquib Ridwan2

  • 1Illinois Institute of Technology, Chicago, IL, USA.

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概括
此摘要是机器生成的。

研究人员开发了MARBLE,这是一种基于MRI的自动化标志物,用于临主导的与年龄相关的TDP-43脑病变神经病理变化 (LATE-NC). 这种工具显示出在老年人中LATE-NC的体内诊断和监测的潜力.

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科学领域:

  • 神经学 神经学
  • 神经成像是一种神经成像.
  • 老年学是指老年学的学科.

背景情况:

  • 边缘主导的与年龄相关的TDP-43脑病变神经病理变化 (LATE-NC) 是老年大脑中常见的发现,但确切的诊断需要尸检.
  • 目前的诊断局限性阻碍了对LATE-NC的及时干预和研究.

研究的目的:

  • 开发和验证LATE-NC.的体内磁共振成像 (MRI) 标记物.
  • 使用神经成像功能创建一个用于LATE-NC诊断的自动化工具.

主要方法:

  • 使用了ex-vivo和in-vivoMRI数据以及纵向衰老研究中的病理学.
  • 开发了一种两级堆叠分类器,使用分数异构,基于变形的形态学和体积.
  • 将分类器打包到一个名为MARBLE (MARker of Brain LatE) 的自动化软件容器中.

主要成果:

  • 活体分类器实现了0.85的AUC,具有77%的平衡精度.
  • 在MARBLE标记物的体内验证显示AUC为0.76.
  • 较高的MARBLE分数与高级LATE-NC阶段有显著的相关性 (p < 0.001).

结论:

  • 马尔伯是一个新的,自动化的,体内MRI标记器,用于LATE-NC.
  • 该工具在体外诊断和监测方面表现出有希望的性能.
  • 需要在独立队列中进一步验证,但MARBLE具有LATE-NC管理的潜力.