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阿尔茨海默氏症成像联盟

Jeffrey S Phillips1, Amanda E Denning2, Lisa M Levorse2

  • 1Penn Frontotemporal Degeneration Center, Department of Neurology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.

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概括
此摘要是机器生成的。

在F-Flortaucipir的PET成像中,在早期的Braak阶段显示出对阿尔茨海默病tau的敏感性. 这种TAU PET标记器主要反映神经纤维状结,而不是线状的TAU结.

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科学领域:

  • 神经成像是一种神经成像.
  • 神经病理学神经病理学
  • 阿尔茨海默氏症疾病研究研究

背景情况:

  • F-Flortaucipir正子发射断层扫描 (PET) 用于阿尔茨海默病 (AD) 图像.
  • 人们担心它在布拉克早期的敏感性和海马体潜在的非目标结合.

研究的目的:

  • 调查死前F-Flortaucipir PET摄入量与死后量化tau和TDP-43神经病理学之间的关联.
  • 为了评估追踪器对早期病理的敏感性.

主要方法:

  • 使用海马体子场T1MRI的自动细分来细分大脑区域.
  • 使用数字成像和弱监督学习 (Wildcat) 的量化tau纠结/线程和pTDP-43包含.
  • 计算F-Flortaucipir标准化吸收值比率 (SUVR) 和量化病理之间的相关性.

主要成果:

  • 超皮质中的F-Flortaucipir SUVRs (BA35/36) 与神经纤维状结相关 (斯皮尔曼的r=0.59,p=0.029).
  • 海马纠负担与前海马和后海马的SUVR相关 (r=0.77,p=0.002).
  • PET SUVRs与体质或神经质pTDP-43测量没有关联.

结论:

  • 18F-Flortaucipir在与早期布拉克阶段相关的区域显示出对tau负担的敏感性.
  • 标记器主要反映神经纤维状结,使其与线区别开来.