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阿尔茨海默氏症成像联盟

Emma F Bublitz1,2,3,4, Carol A Van Hulle3, Hannah Zylstra5

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概括
此摘要是机器生成的。

伊科萨乙烯 (IPE) 在退伍军人中没有显著改变大脑血流. 然而,基线血管大脑脊髓液 (CSF) 生物标志物与大脑血液流量指标相关,与APOE ε4载体状态不同.

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科学领域:

  • 神经学 神经学
  • 心血管医学 心血管医学
  • 放射学 放射学是一门学科.

背景情况:

  • 退伍军人患血管疾病和阿尔茨海默病 (AD) 的风险更高.
  • 伊科萨乙烯 (IPE) 是一种omega-3脂肪酸,可以减少心血管事件和甘油三.
  • IPE可能改善血管健康,可能降低AD风险.

研究的目的:

  • 为了研究IPE对退伍军人的脑血管健康的影响,使用4D流动MRI (PCVIPR).
  • 在退伍军人中探索IPE,APOE基因型和脑脊液 (CSF) 生物标志物的关系.

主要方法:

  • BRAVE-EPA研究是一项随机,双盲,安慰剂控制的试验,涉及123名认知不受损的退伍军人.
  • 参与者每天接受4克IPE或安慰剂18个月,接受PCVIPRMRI和CSF生物标志物分析.
  • 使用PCVIPR测量脑血流 (MF,PI,CBF),分析包括曼-惠特尼U测试和相关性.

主要成果:

  • IPE治疗没有显著改变平均血流量 (MF),脉动率指数 (PI) 或总脑血流量 (CBF).
  • APOE ε4 携带者和非携带者表现出类似的基线血流.
  • 基线CSF血管生物标志物与PI显著相关,并且在较小程度上与MF相关.

结论:

  • 在这组退伍军人中,IPE治疗没有显著影响PCVIPR测量的脑血流.
  • 基线CSF血管生物标志物水平,而不是APOE ε4状态,与基线脑血流脉动性和平均流量有关.