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阿尔茨海默氏症成像联盟

Julia H Cho1, Brice Passera2, Recep Ozdemir2

  • 1Harvard Medical School, Boston, MA, USA.

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概括
此摘要是机器生成的。

在阿尔茨海默氏病 (AD) 中,用电肌图 (EMG) 进行的跨磁刺激 (TMS) 显示皮质刺激性增加. 这一发现,特别是在更高的刺激强度下,表明了AD的潜在新治疗点.

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科学领域:

  • 神经科学是一个神经科学.
  • 神经学 神经学
  • 生物医学工程 生物医学工程

背景情况:

  • 阿尔茨海默氏症 (AD) 与皮质刺激异常有关,可能导致疾病的进展.
  • 目前在阿尔茨海默病患者中评估皮质刺激性的非侵入性方法是有限的.
  • 与粉样蛋白相关的过度兴奋性可能与更快的临床衰退和病理传播有关.

研究的目的:

  • 通过一种新的输入-输出 (I/O) 响应曲线方法,研究早期阿尔茨海默病中的皮层刺激机制.
  • 为了比较早期阿尔茨海默症患者和认知正常的老年人之间的皮层刺激性.
  • 通过电肌图 (EMG) 建立跨磁刺激 (TMS) 作为评估AD相关皮质刺激性的工具.

主要方法:

  • 招募了52名早期AD患者和51名认知正常 (CN) 的老年人.
  • 使用单脉冲TMS和电肌学 (EMG) 来测量静止运动值 (RMT),并通过变化刺激强度生成I/O曲线.
  • 分析了使用线性混合效应模型的运动唤起潜力 (MEP),控制了相关的共变量.

主要成果:

  • 与CN个体相比,患有早期AD的个体表现出较低的RMT,这表明皮质刺激性增加.
  • 在AD组中,I/O曲线显示皮层刺激性显著增加,特别是在更高的刺激强度下.
  • 在AD患者中,增强的反应在RMT相对于最大刺激器输出的135-150%时最为明显.

结论:

  • TMS-EMG证实在早期的AD中皮层刺激性增加,这表明电压关闭的Na+通道和AMPA受体的参与.
  • 开发的I/O曲线方法有效地区分了AD患者和对照人群之间的皮质刺激性.
  • 在阿尔茨海默病临床试验中,TMS-EMG显示出作为测量皮质刺激能力治疗效应的工具的前景.