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阿尔茨海默氏症成像联盟

Jacqueline Rizzo1, Hope Shimony1, Charles D Chen1,2

  • 1Washington University School of Medicine, St. Louis, MO, USA.

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概括
此摘要是机器生成的。

较新的FreeSurfer版本与旧版本相比,显示了显著的体积测量变化. 这些在FreeSurfer中的差异 (例如小脑皮层) 可能会影响其他成像量化方法.

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科学领域:

  • 神经成像是一种神经成像.
  • 医学图像分析 医学图像分析
  • 大脑成像软件 大脑成像软件

背景情况:

  • FreeSurfer 是用于在MRI扫描中对大脑区域进行细分的标准工具.
  • 区域体积测量对于神经成像中的定量分析至关重要.
  • 最近的FreeSurfer更新需要对各版本的体积输出进行比较.

研究的目的:

  • 为了比较FreeSurfer-5.3和FreeSurfer-7.4.4之间的区域体积测量.
  • 评估FreeSurfer-5.3.3中的测试-重新测试变异性.
  • 在体积测量中量化反转间变量的测量.

主要方法:

  • 从18名参与者中获得了两个T1加权的MRI扫描.
  • 扫描使用Dockerized FreeSurfer-5.3进行了处理,用于测试复试分析.
  • 第一个扫描用FreeSurfer-7.4处理,以比较版本间的差异.

主要成果:

  • 在拦截中观察到显著的测试-重试变异性.
  • 版本间分析显示皮层和皮层下体积的显著变化.
  • 最大的差异是在小脑白质,近海马体和下体体积中观察到的.

结论:

  • 在FreeSurfer-5.3和FreeSurfer-7.4.4之间,体积测量有很大的差异.
  • 像小脑皮层这样的区域显示出实质性的互转变差异.
  • 这些FreeSurfer版本差异对其他成像模式的影响需要调查.