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阿尔茨海默氏症成像联盟

Alejandra O Morcillo-Nieto1,2, Mateus Rozalem Aranha2,3, José Enrique Arriola-Infante1,2

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概括
此摘要是机器生成的。

白质超强度 (WMH) 在唐氏综合征 (DS) 患者中随着时间的推移出乎意料地减少,特别是那些有症状的阿尔茨海默病 (AD) 患者. 这一发现为DS中的WMH病因和潜在的干预目标提供了新的见解.

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科学领域:

  • 神经成像是一种神经成像.
  • 神经学 神经学
  • 遗传学 是一个遗传学.

背景情况:

  • 唐氏综合症 (DS) 是阿尔茨海默病 (AD) 的遗传形式,血管风险因素较低.
  • 白质超强度 (WMH) 在DS中很常见,与小血管疾病和神经退行有关.
  • 目前尚不清楚WMH的时间变化及其与AD病理学的联系.

研究的目的:

  • 在AD连续体中调查DS个体中WMH的纵向演变.
  • 确定WMH变化与DS的基线临床和病理特征之间的关联.

主要方法:

  • 长度MRI研究86名DS患者 (无症状和症状AD) 和47名健康对照.
  • 在FLAIR图像上使用纵向管道进行WMH细分.
  • 分析WMH体积变化与年龄,AD临床阶段,CSFAD生物标志物和微型血液状况的关系.

主要成果:

  • 与健康对照群不同的是,DS患者的WMH体积随着年龄的增长而显著下降.
  • 这种减少在有症状的AD (sDS) 中比无症状的AD (aDS) 更明显.
  • CSF pTau181和NfL水平与WMH变化相关,而Aβ42 / Aβ40比率没有.

结论:

  • 随着时间的推移,WMH在DS下降,特别是在具有高基线WMH的sDS中,这一发现不能由缩解释.
  • 这挑战了以前关于DS中WMH进展的假设.
  • 提供了对DS中WMH病因学的新见解,并强调WMH是针对性干预的潜在结果.