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Hybrid PET/MRI Imaging of Alzheimer's Disease Based on 18F-AV-1451
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阿尔茨海默氏症成像联盟

Linda Zhang1, Jesús Silva-Rodríguez1, Eva Alfayate1

  • 1CIEN Foundation, Reina Sofia Alzheimer Center, ISCIII, Madrid, Madrid, Spain.

Alzheimer's & dementia : the journal of the Alzheimer's Association
|December 23, 2025
PubMed
概括

在没有认知障碍的个体中,血p-tau217水平升高与阿尔茨海默病 (AD) 相关大脑区域的皮质平均扩散率 (MD) 增加有关. 这些发现表明早期的AD相关的微观结构变化可以通过MRI检测到.

科学领域:

  • 神经成像是一种神经成像.
  • 生物标志物 生物标志物
  • 阿尔茨海默氏症疾病研究研究

背景情况:

  • 血p-tau217是早期阿尔茨海默病 (AD) 病理学的可靠生物标志物.
  • 从扩散加权成像中得到的皮质平均扩散度 (MD) 可能反映了神经退行性疾病的早期微观结构变化.
  • 在认知不受损的个体中,血p-tau217和皮质MD之间的关系尚未研究.

研究的目的:

  • 为了研究血p-tau217水平和皮质平均扩散度 (MD) 在认知不受损的老年人之间的关联.
  • 为了确定是否升高的p-tau217与早期AD中MRI检测到的微观结构变化有关.

主要方法:

  • 从瓦莱卡斯项目队列中对1029名认知不受损的老年参与者的横截面分析.
  • 使用LUMIPULSE平台测量血p-tau217水平;参与者被分类为p-tau217+或p-tau217-.
  • 分析了扩散权重的MRI数据,以获得皮质灰质MD图,以控制年龄和性别的voxel-wise GLM分析.

主要成果:

  • 而p-tau217+组的年龄明显大于p-tau217组.
  • 在对年龄和性别进行控制后,p-tau217+组表现出显著更高的皮质MD.
  • 在p-tau217+组中,在双边中间时 (杏仁体,海马体) 和岛屿区域观察到升高的MD.

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结论:

  • 在没有认知障碍的个体中,可以检测到皮层MD变化,具有高血p-tau217.21的认知障碍.
  • 这些观察到的MD变化发生在通常与AD神经病理学相关的大脑区域.
  • 目前正在进行对该队列中MD变化的纵向分析.