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阿尔茨海默氏症成像联盟

Alejandra O Morcillo-Nieto1,2, José Enrique Arriola-Infante1,2, Maria Franquesa-Mullerat2

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概括
此摘要是机器生成的。

骨化平均扩散率 (PSMD) 的峰值宽度显示了唐氏综合征 (DS) 个体的早期白质变化,先于阿尔茨海默病 (AD) 症状. 这种扩散张力成像 (DTI) 标记物对DS的AD病理和小血管疾病 (SVD) 敏感.

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科学领域:

  • 神经成像是一种神经成像.
  • 遗传学 是一个遗传学.
  • 神经学 神经学

背景情况:

  • 唐氏综合征 (DS) 给阿尔茨海默氏症 (AD) 带来了异常高的风险.
  • 患有DS的个体通常表现出小血管疾病 (SVD) 的放射性迹象,尽管血管风险因素的流行率较低.
  • 骨化平均扩散率 (PSMD) 的峰值宽度是一种扩散张力成像 (DTI) 标记,用于量化脑SVD造成的白质 (WM) 损伤.

研究的目的:

  • 在患有DS的个体中调查整个AD连续性的PSMD变化.
  • 确定PSMD与DS中的AD和SVD生物标志物的关联.

主要方法:

  • 一项涉及70名健康对照 (HC) 和140名DS患者 (无症状,前期AD和AD痴呆症) 的横截面研究.
  • 进行了包括DTI在内的3T-MRI;使用自动管道提取PSMD.
  • 分析了与社会人口统计学因素,血管风险因素 (VRF),AD脑脊液 (CSF) 生物标志物和SVD标志物 (WM超强度[WMH],微血) 的关联.

主要成果:

  • 在DS中,PSMD的年龄关联比HC更强,在42岁左右出现分歧.
  • 随着AD连续性,PSMD线性增加 (HC <无症状DS <前发性DS =痴呆DS).
  • PSMD与AD CSF生物标志物相关,并且在微型血液和WMH的DS中显著增加.

结论:

  • 在DS中PSMD的变化开始在临床AD症状出现前10-15年.
  • 随着AD临床阶段,AD病理和SVD指标的增加,PSMD显示出线性增加.
  • 作为一种敏感的生物标志物,PSMD显示出有前途的潜力,用于早期检测患有DS的成年人的白质变化.