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阿尔茨海默氏症成像联盟

Olujide Oyeniran1, Kirsty Donald2, Akintunde Orunmuyi3

  • 1Lawson Health Research Institute, London, ON, Canada.

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概括
此摘要是机器生成的。

非洲面临着严重的阿尔茨海默病和相关痴呆症 (ADRD) 负担,但缺乏必要的神经成像研究能力. 弥合这一差距需要对基础设施,技术和人员培训进行大量投资.

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科学领域:

  • 神经科学是一个神经科学.
  • 医疗成像医学成像
  • 公共卫生 公共卫生

背景情况:

  • 预计在未来几十年里,非洲的阿尔茨海默病和相关痴呆症 (ADRD) 患病率将很高.
  • 像MRI和PET这样的神经成像工具对于ADRD的表征至关重要,但在非洲尚未充分利用.
  • 发展神经成像能力,以在非洲不同的人群中开展痴呆症研究,是非常必要的.

研究的目的:

  • 为突出痴呆症成像研究的全球差距.
  • 在非洲识别神经成像使用障碍.
  • 提出在非洲各地启用痴呆症神经成像研究的机会.

主要方法:

  • 从文献和临床试验数据库中使用MRI或PET审查了全球ADRD研究.
  • 估计的研究地点,参与者数量和容量.
  • 评估了非洲的成像基础设施,人员需求和相关成本.

主要成果:

  • 在全球范围内,ADRD神经成像研究仅集中在49个国家,非洲的研究地点和参与者最少.
  • 只有四个非洲国家进行了基于MRI的ADRD研究;没有报告PET研究.
  • 基础设施的高成本,无线电追踪器和熟练人员的短缺是主要障碍,需要大约293亿美元的投资.

结论:

  • 增加对具有成本效益的成像基础设施的投资至关重要.
  • 建议优化现有的临床成像系统,以进行先进的研究.
  • 合作培训计划和建立区域/全球伙伴关系可以提高非洲痴呆症成像能力.