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Alzheimer's Disease: Overview01:26

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Alzheimer's Disease (AD) is a continually advancing neurodegenerative disorder, distinguished by escalating memory loss, cognitive dysfunction, and dementia. The disease unfolds in three stages: preclinical, mild cognitive impairment (MCI), and dementia. Its onset is insidious, and the progression gradual, with the cause not well explained by other disorders.
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DefinitionComputed Tomography (CT) of the genitourinary (GU) tract is a non-invasive imaging modality that utilizes X-rays and computer processing to generate detailed cross-sectional images of the urinary system, encompassing the kidneys, ureters, bladder, and adjacent structures such as the adrenal glands.PurposeCT scans of the GU tract serve several diagnostic and therapeutic purposes, including:Diagnosis of Urinary Tract Diseases: Detects kidney stones, tumors, cysts, and congenital...
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Introduction:Magnetic Resonance Imaging, or MRI, can include a specialized imaging technique of the urinary system known as Magnetic Resonance Urography (MRU). This radiation-free technique uses strong magnetic fields and radio waves to produce detailed images with the help of a computer. MRU is particularly effective for visualizing fluid-filled structures like the kidneys, ureters, and bladder.Applications of MRI in the Genitourinary SystemKidneys and Ureters: MRI detects tumors, cysts,...
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阿尔茨海默氏症成像联盟

Niklas Behrenbruch1,2,3, Svenja Schwarck1,2, Beate Schumann-Werner1,2

  • 1German Center for Neurodegenerative Diseases (DZNE), Magdeburg, Germany.

Alzheimer's & dementia : the journal of the Alzheimer's Association
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概括
此摘要是机器生成的。

积极的生活方式,包括身体健康和精神活动,促进老年人的大脑健康和认知性. 阿尔茨海默病的遗传风险可能会加速大脑衰老,即使在健康个体中也是如此.

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科学领域:

  • 神经科学是一个神经科学.
  • 老年学是指老年学的学科.
  • 公共卫生 公共卫生

背景情况:

  • 老龄化与认知能力下降有关,但弹性和病理耐药性的个体差异显著.
  • 要了解生活方式,健康和大脑衰老的相互作用,需要采用多式联络方法.
  • 阿尔茨海默病 (AD) 的遗传风险和生物标志物为病态衰老过程提供了洞察力.

研究的目的:

  • 描述老年人生活方式,精神和身体健康的潜在结构.
  • 估计大脑和认知衰老的指数,包括病理标志物.
  • 研究生活方式/健康状况,AD遗传风险和大脑/认知衰老之间的关系.

主要方法:

  • 对211名认知正常的老年人 (≥60岁) 的分析,使用30个生活方式/健康变量的主成分分析 (PCA).
  • 计算大脑年龄差距 (BAG) 和认知年龄差距 (CAG),结合AD病理,白质超强度和扩大的周血管空间.
  • 在BAG和CAG上对生活方式/健康主要成分 (PC) 的回归分析,以及APOE e4载体的t测试.

主要成果:

  • 活跃的生活方式 (PC2) 与较低的脑年龄差距 (BAG) 和认知年龄差距 (CAG) 相关.
  • 精神休活动与认知年龄差距 (CAG) 有关,独立于大脑病理.
  • 携带APOE e4的患者的BAG显著更高,这表明大脑衰老加速.

结论:

  • 积极的生活方式包括身体健康和精神参与,促进认知性和大脑维护.
  • 精神休活动可能会赋予认知性,而不依赖于潜在的大脑病理.
  • 对阿尔茨海默病的遗传倾向可以在认知健康的老年人中加速大脑衰老.