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阿尔茨海默氏症成像联盟

Jazlynn Xiu Min Tan1, Min Su Kang2, Yi-Hsuan Yeh2

  • 1Department of Medical Biophysics, University of Toronto, Toronto, ON, Canada.

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概括
此摘要是机器生成的。

这项研究揭示了病理是如何通过阿尔茨海默病 (AD) 中改变的大脑网络传播的. 随着疾病的进展,tau连接在大脑组织梯度上发生了变化,突出显示了网络重组.

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科学领域:

  • 神经科学是一个神经科学.
  • 神经成像是一种神经成像.
  • 在Connectomics上,我们提供了连接.

背景情况:

  • 之前关于传播的研究集中在解剖空间内的短距离连接上.
  • 这项研究引入了连接体梯度,这是一种反映大脑层次的新型坐标系统,用于分析长距离连接的tau传播.
  • 在这个新的框架中了解tau的传播,可以了解网络的改变和阿尔茨海默病 (AD) 的易感性.

研究的目的:

  • 用连接体梯度来研究tau沿着远程连接传播.
  • 探索与阿尔茨海默病中tau病理相关联的连接模式的改变.
  • 要了解的传播如何与大脑的层次组织和网络易感性有关.

主要方法:

  • 包括213名参与者 (A-CN,A+CN,A+CI) 进行扩散权重MRI,静止状态fMRI和18F-MK6240 tau-PET.
  • 采用基于图形理论的逐步连接分析来绘制从内腔皮层的远程连接.
  • 在一个由功能和结构连接体梯度定义的坐标系内,研究了与tau相关的连接性模式.

主要成果:

  • 在临床前的AD (A+CN) 与对照组 (A-CN) 相比,在功能梯度空间中显示出更高的连接性.
  • 临床AD (A+CI) 呈现出从内腔皮层到特定梯度末端 (跨模态/DMN/边缘和后部/temporo-occipital) 的连接性减少.
  • -连接性相关性随着疾病进展而在梯度空间内空间转移,表明网络重组.

结论:

  • 逐步连接和连接体梯度的新整合增强了对沿主要大脑组织轴传播的tau的理解.
  • 在阿尔茨海默病中观察到广泛的网络重组.
  • 在疾病进展过程中,tau-连接性相关性在主要功能连接体网络之间发生变化.