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Alzheimer's Disease (AD) is a continually advancing neurodegenerative disorder, distinguished by escalating memory loss, cognitive dysfunction, and dementia. The disease unfolds in three stages: preclinical, mild cognitive impairment (MCI), and dementia. Its onset is insidious, and the progression gradual, with the cause not well explained by other disorders.
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DefinitionComputed Tomography (CT) of the genitourinary (GU) tract is a non-invasive imaging modality that utilizes X-rays and computer processing to generate detailed cross-sectional images of the urinary system, encompassing the kidneys, ureters, bladder, and adjacent structures such as the adrenal glands.PurposeCT scans of the GU tract serve several diagnostic and therapeutic purposes, including:Diagnosis of Urinary Tract Diseases: Detects kidney stones, tumors, cysts, and congenital...
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Introduction:Magnetic Resonance Imaging, or MRI, can include a specialized imaging technique of the urinary system known as Magnetic Resonance Urography (MRU). This radiation-free technique uses strong magnetic fields and radio waves to produce detailed images with the help of a computer. MRU is particularly effective for visualizing fluid-filled structures like the kidneys, ureters, and bladder.Applications of MRI in the Genitourinary SystemKidneys and Ureters: MRI detects tumors, cysts,...
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阿尔茨海默氏症成像联盟

Cyrus A Raji1, Somayeh Meysami2,3, Soojin Lee4

  • 1Mallinckrodt Institute of Radiology, Washington University in St. Louis, St. Louis, MO, USA.

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概括
此摘要是机器生成的。

2型糖尿病和高内脏脂肪与大脑体积减少有关,特别是在易患阿尔茨海默病 (AD) 的区域. 这些因素是中年预防神经退行症策略的关键目标.

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科学领域:

  • 神经科学是一个神经科学.
  • 内分泌学 在内分泌学.
  • 放射学 放射学是一门学科.

背景情况:

  • 痴呆症,包括阿尔茨海默病 (AD),越来越多地被认为是可以预防的,高达45%的病例与可修改的风险因素有关.
  • 较高的内脏脂肪与对早期AD病理易感的大脑区域的缩有关,例如海马体和后带带状.

研究的目的:

  • 研究高内脏脂肪和2型糖尿病对大脑体积损失的综合影响,这是神经退行的一个关键指标.
  • 为了探索内脏脂肪,2型糖尿病和特定神经解剖学区域的大脑缩之间的关系.

主要方法:

  • 一项涉及4,213名成年人的横截面研究,使用1.5T的全身MRI.
  • 深度学习模型量化了内脏脂肪组织 (VAT) 和大脑体积,包括海马体和后侧环状回.
  • 分析对2型糖尿病和高VAT患者的大脑体积进行了比较,以对照者进行调整,以年龄,性别和总内体积为准.

主要成果:

  • 患有2型糖尿病和最高四分之一增值税的个体表现出明显较低的全脑辅酶体积.
  • 在高VAT的2型糖尿病患者中观察到海马和后带带状回形体积的减少.
  • 两组之间没有发现先体积的显著差异.

结论:

  • 2型糖尿病结合高内脏脂肪与阿尔茨海默病易受影响的区域的大脑体积减少有关.
  • 这些发现突出了2型糖尿病和内脏肥胖症作为二次预防AD的关键目标,即使在中年.
  • 可修改的风险因素,如2型糖尿病和内脏肥胖症,通过生活方式和药物干预措施为AD风险减轻提供了有希望的途径.