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阿尔茨海默氏症成像联盟

Andrew K McVea1, Max McLachlan2, Brecca Bettcher2

  • 1University of Wisconsin - Madison, Madison, WI, USA.

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概括
此摘要是机器生成的。

携带APOE4的女性和女性显示较高[F-18]MK6240脑膜信号,影响阿尔茨海默病PET成像. 考虑到APOE4携带和性别对于准确的MK6240量化和比较至关重要.

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科学领域:

  • 神经成像是一种神经成像.
  • 阿尔茨海默氏症疾病研究研究
  • 无线电联网发展与发展

背景情况:

  • 具有APOE4等位基因的个体有阿尔茨海默病 (AD) 的终身风险增加,包括粉样蛋白和病理的早期发病.
  • [F-18]MK6240是一种PET射线连体,用于在AD中成像tau聚合物,但非目标脑膜信号可能会影响量化.
  • 之前的研究发现女性脑膜[F-18]MK6240信号较高,并且依赖扫描仪模型.

研究的目的:

  • 为了比较脑膜[F-18]MK6240信号大小和APOE4载体和非载体之间的分布.
  • 为了研究APOE4载体对TAU PET成像的影响.
  • 评估阿尔茨海默病PET量化中的潜在偏差.

主要方法:

  • 1051名参与者使用PET在Biograph Horizon mCT或ECAT HR+扫描仪进行扫描.
  • 标准化管道生成了SUVR图像,使用5mm稀释的皮质面膜用于脑膜ROI分析.
  • 多重回归比较了APOE4载体和非载体之间的脑膜SUVR,包括性别和扫描仪模型作为共变量.

主要成果:

  • 在APOE4携带者 (p=0.03),女性 (p<0.001) 和mCT扫描仪 (p<0.001) 中观察到更高的平均脑膜[F-18]MK6240信号.
  • 在变量之间没有发现任何显著的相互作用条款.
  • 对女性的敏感性分析显示,在HR+ (p=0.009) 和mCT (p=0.05) 上,APOE4载体的脑膜信号显著更高.

结论:

  • 脑膜[F-18]MK6240信号变异性可以在阿尔茨海默病研究中偏差tau PET结果.
  • 携带APOE4和性别是影响脑膜信号的重要因素.
  • 这些关系必须考虑在AD研究中准确的MK6240量化和人群比较.