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阿尔茨海默氏症成像联盟

Nidhi S Mundada1, Xueying Lyu1, Niyousha Sadeghpour1

  • 1University of Pennsylvania, Philadelphia, PA, USA.

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概括
此摘要是机器生成的。

较低的海马体积确定在阿尔茨海默病 (AD) 患者的边缘主导的与年龄相关的TDP-43脑病变 (LATE). 这一发现有助于诊断混合AD/LATE病例并了解疾病进展.

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科学领域:

  • 神经科学是一个神经科学.
  • 神经病理学神经病理学
  • 放射学 放射学是一门学科.

背景情况:

  • 诊断混合阿尔茨海默病 (AD) 和边缘主导的与年龄相关的TDP-43脑病变 (LATE) 是具有挑战性的,因为症状重叠和缺乏体内生物标志物.
  • 尸体解剖研究表明,在AD患者中,海马缩大,同时发生LATE.
  • 识别AD和LATE患者对于准确的诊断和治疗至关重要.

研究的目的:

  • 为了识别沿着AD连续的患者,谁是丰富的LATE.
  • 利用海马体积 (HV) 的下四分位数作为LATE的潜在生物标志物.
  • 在混合AD/LATE病例中探索不同的缩模式和认知概况.

主要方法:

  • 从ADNI中164名认知障碍的参与者接受了T1-MRI和粉样蛋白/tau-PET扫描.
  • 根据HV四分位数和粉样蛋白状况,参与者被分为AD-only,LATE-only和AD+LATE组.
  • 基于表面的区域厚度分析检查了中间叶 (MTL) 的缩模式和四个领域的认知差异.

主要成果:

  • 与AD+LATE组相比,AD+LATE组表现出LATE的成像特征,较低的认知得分和较高的tau-PET吸收,与AD-only相比.
  • AD+LATE显示出比AD-only更严重的前海马和杏仁体缩,与LATE-only类似的模式.
  • 从长度来看,AD+LATE在所有领域都表现出更快的认知衰退,这表明疾病的过程更具侵略性.

结论:

  • 较低的HV四分位数可以识别AD连续的LATE样模式的患者,表明潜在的LATE病理.
  • 这种基于HV百分位数的指标可以帮助在临床试验中识别混合AD/LATE病例.
  • 这些发现支持HV作为LATE生物标志物的相关性,在AD研究的背景下.