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阿尔茨海默氏症成像联盟

Vikas Kotari1, Karen Chilcott Holdridge2, Roy Yaari2

  • 1Eli Lilly and Company, Indianapolis, IN, USA.

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概括
此摘要是机器生成的。

在临床前阿尔茨海默氏症 (AD) 中,tau PET扫描显示,tau积累存在于认知不受损的个体的一个子集中,在轻度认知障碍的人群中水平更高. 这些发现与先前关于AD中沉积模式的研究一致.

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科学领域:

  • 神经学 神经学
  • 放射学 放射学是一门学科.
  • 老年学是一门学科.

背景情况:

  • 临床前阿尔茨海默氏症 (AD) 的特点是粉样蛋白积累,但往往没有认知障碍.
  • 之前的试验表明,在临床前阿尔茨海默病患者中,全球TAU升高的患病率较低.
  • 在TRAILBLAZER-ALZ 3试验调查donanemab在临床前阿尔茨海默病的疗效,需要基线tau的表征.

研究的目的:

  • 描述和比较TRAILBLAZER-ALZ 3试验中的基线定子发射断层扫描 (PET) 扫描.
  • 为了将tau PET的发现与A4和TRAILBLAZER-ALZ 2研究的发现进行比较.
  • 评估临床前阿尔茨海默病患者群体中的tau负担和区域模式.

主要方法:

  • 在TRAILBLAZER-ALZ 3试验中的310名参与者的基线tau PET扫描 (flortaucipir F18) 的分析.
  • 参与者根据临床痴呆症评分-全球分数 (CDR-GS 0和CDR-GS 0.5) 分类.
  • 使用标准化吸收值比率 (SUVR) 量化全球tau负担,并确定了切割点;使用分阶段方案评估区域tau模式.

主要成果:

  • 13.3%的CDR0和25.5%的CDR0.5参与者显示出阳性PET扫描 (SUVR>1.11).
  • 这两个小组在中侧叶和侧侧叶中表现出最高的区域性SUVR.
  • 与CDR0亚组相比,CDR0.5亚组的平均区域SUVR高于CDR0亚组.

结论:

  • 在TRAILBLAZER-ALZ 3中基线tau PET模式与其他临床前阿尔茨海默病群体相一致,包括CDR0.5亚组.
  • 这些发现支持沉积的顺序模式:中叶,侧叶,叶和额叶.
  • 需要进一步进行区域分析,以充分阐明临床前AD中tau的分布.